3-Benzoyl-1-((2S,5R,6S)-6-hydroxy-spiro[4.4]non-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:3-Benzoyl-1-((2S,5R,6S)-6-hydroxy-spiro[4.4]non-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:511549-98-7
Molecular Formula:C₂₁H₂₄N₂O₄
Molecular Weight:368.433
Hs Code.:

Synonyms:3-Benzoyl-1-((2S,5R,6S)-6-hydroxy-spiro[4.4]non-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Property of 3-Benzoyl-1-((2S,5R,6S)-6-hydroxy-spiro[4.4]non-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

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Technology Process of 3-Benzoyl-1-((2S,5R,6S)-6-hydroxy-spiro[4.4]non-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

There total 7 articles about 3-Benzoyl-1-((2S,5R,6S)-6-hydroxy-spiro[4.4]non-2-yl)-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 511549-97-6
3-benzoyl-1-[6-(tert-butyl-dimethyl-silanyloxy)-spiro[4.4]non-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 511549-98-7
3-Benzoyl-1-((2S,5R,6S)-6-hydroxy-spiro[4.4]non-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1021/ol0340033

Reference yield:

: 511549-91-0
tert-Butyl-dimethyl-((1S,5R)-spiro[4.4]non-6-en-1-yloxy)-silane

: 511549-98-7
3-Benzoyl-1-((2S,5R,6S)-6-hydroxy-spiro[4.4]non-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: disiamylborane

1.2: 51 percent / hydrogen peroxide / Alkaline hydrolysis

2.1: 43 percent / diisopropyl azodicarboxylate; triphenylphosphine

3.1: 79 percent / tetra-n-butylammonium fluoride / tetrahydrofuran

With di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; bis-(1,2-dimethylpropyl)borane; triphenylphosphine; In tetrahydrofuran; 2.1: Mitsunobu reaction;
DOI:10.1021/ol0340033

Reference yield:

: (1S,5S,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-spiro[4.4]nonan-1-ol

: 511549-98-7
3-Benzoyl-1-((2S,5R,6S)-6-hydroxy-spiro[4.4]non-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: 56 percent / phosphorus oxychloride; pyridine

2.1: disiamylborane

2.2: 51 percent / hydrogen peroxide / Alkaline hydrolysis

3.1: 43 percent / diisopropyl azodicarboxylate; triphenylphosphine

4.1: 79 percent / tetra-n-butylammonium fluoride / tetrahydrofuran

With pyridine; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; bis-(1,2-dimethylpropyl)borane; triphenylphosphine; trichlorophosphate; In tetrahydrofuran; 3.1: Mitsunobu reaction;
DOI:10.1021/ol0340033