4-chloro-N-(3-((4-hydroxy-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide

Base Information

Chemical Name:4-chloro-N-(3-((4-hydroxy-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide
CAS No.:1333144-83-4
Molecular Formula:C₂₀H₂₀ClNO₄S
Molecular Weight:405.902
Hs Code.:

Synonyms:4-chloro-N-(3-((4-hydroxy-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide

Suppliers and Price of 4-chloro-N-(3-((4-hydroxy-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-chloro-N-(3-((4-hydroxy-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide

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Technology Process of 4-chloro-N-(3-((4-hydroxy-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide

There total 11 articles about 4-chloro-N-(3-((4-hydroxy-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1333144-74-3
4-chloro-N-(3-((4-isobutoxy-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide

: 1333144-83-4
4-chloro-N-(3-((4-hydroxy-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide

Guidance literature:: With hydrogenchloride; In water; acetone; at 20 ℃; for 6h;
DOI:10.1021/jm200980u

Reference yield:

: 1333144-57-2
3-(2-((triisopropylsilyl)oxy)ethyl)benzaldehyde

: 1333144-83-4
4-chloro-N-(3-((4-hydroxy-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; water / 2 h / Reflux

2.1: 1H-imidazole; iodine; triphenylphosphine / diethyl ether; acetonitrile / 2 h / 0 °C

3.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.75 h / -78 °C

3.2: -78 - 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 °C

5.1: 1H-imidazole; iodine; triphenylphosphine / diethyl ether; acetonitrile / 2 h / 0 °C

6.1: sodium azide / N,N-dimethyl-formamide / 0.75 h / 50 °C

7.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C / 760.05 Torr

8.1: sodium hydroxide / methanol; water / 4 h / 0 °C

9.1: hydrogenchloride / water; acetone / 6 h / 20 °C

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; sodium azide; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; iodine; triphenylphosphine; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; hexane; water; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jm200980u

Reference yield:

: 1333144-58-3
3-(2-((triisopropylsilyl)oxy)ethyl)phenylmethanol

: 1333144-83-4
4-chloro-N-(3-((4-hydroxy-2-oxocyclopent-3-en-1-yl)methyl)phenethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1H-imidazole; iodine; triphenylphosphine / diethyl ether; acetonitrile / 2 h / 0 °C

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.75 h / -78 °C

2.2: -78 - 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 °C

4.1: 1H-imidazole; iodine; triphenylphosphine / diethyl ether; acetonitrile / 2 h / 0 °C

5.1: sodium azide / N,N-dimethyl-formamide / 0.75 h / 50 °C

6.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C / 760.05 Torr

7.1: sodium hydroxide / methanol; water / 4 h / 0 °C

8.1: hydrogenchloride / water; acetone / 6 h / 20 °C

With 1H-imidazole; hydrogenchloride; sodium azide; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; iodine; triphenylphosphine; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; hexane; water; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jm200980u