1-(3-aminopropanoyl)-N-(3,5-bis(4-carbamimidoylphenoxy)phenyl)piperidine-4-carboxamide

Base Information

Chemical Name:1-(3-aminopropanoyl)-N-(3,5-bis(4-carbamimidoylphenoxy)phenyl)piperidine-4-carboxamide
CAS No.:1256590-63-2
Molecular Formula:C₂₉H₃₃N₇O₄
Molecular Weight:543.626
Hs Code.:

Synonyms:1-(3-aminopropanoyl)-N-(3,5-bis(4-carbamimidoylphenoxy)phenyl)piperidine-4-carboxamide

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Chemical Property of 1-(3-aminopropanoyl)-N-(3,5-bis(4-carbamimidoylphenoxy)phenyl)piperidine-4-carboxamide

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Technology Process of 1-(3-aminopropanoyl)-N-(3,5-bis(4-carbamimidoylphenoxy)phenyl)piperidine-4-carboxamide

There total 11 articles about 1-(3-aminopropanoyl)-N-(3,5-bis(4-carbamimidoylphenoxy)phenyl)piperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: (3-{4-[3,5-Bis-(4-carbamimidoyl-phenoxy)-phenylcarbamoyl]-piperidin-1-yl}-3-oxo-propyl)-carbamic acid tert-butyl ester

: 1256590-63-2
1-(3-aminopropanoyl)-N-(3,5-bis(4-carbamimidoylphenoxy)phenyl)piperidine-4-carboxamide

Guidance literature:: With hydrogenchloride; ethanol; at 5 - 10 ℃; for 2h;
DOI:10.1016/j.bmc.2014.04.013

Reference yield:

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 1256590-63-2
1-(3-aminopropanoyl)-N-(3,5-bis(4-carbamimidoylphenoxy)phenyl)piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 80 °C

2.1: lithium hydroxide; water / tetrahydrofuran / 2 h

3.1: N-ethyl-N,N-diisopropylamine; diphenylphosphoranyl azide / 12 h / 80 °C

4.1: water; hydrogenchloride / ethanol / 2 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 5 °C

5.2: 6 h / 20 °C

6.1: hydroxylamine / ethanol; water / 6 h / 75 °C

7.1: acetic acid / 2 h / 20 °C

8.1: acetic acid; zinc / 20 °C

9.1: hydrogenchloride; ethanol / 2 h / 5 - 10 °C

With hydrogenchloride; ethanol; diphenylphosphoranyl azide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; hydroxylamine; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; zinc; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; 3.1: |Curtius Rearrangement;
DOI:10.1016/j.bmc.2014.04.013

Reference yield:

: 1256592-07-0
ethyl 3,5-bis(4-cyanophenoxy)benzoate

: 1256590-63-2
1-(3-aminopropanoyl)-N-(3,5-bis(4-carbamimidoylphenoxy)phenyl)piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium hydroxide; water / tetrahydrofuran / 2 h

2.1: N-ethyl-N,N-diisopropylamine; diphenylphosphoranyl azide / 12 h / 80 °C

3.1: water; hydrogenchloride / ethanol / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 5 °C

4.2: 6 h / 20 °C

5.1: hydroxylamine / ethanol; water / 6 h / 75 °C

6.1: acetic acid / 2 h / 20 °C

7.1: acetic acid; zinc / 20 °C

8.1: hydrogenchloride; ethanol / 2 h / 5 - 10 °C

With hydrogenchloride; ethanol; diphenylphosphoranyl azide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; hydroxylamine; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; zinc; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; 2.1: |Curtius Rearrangement;
DOI:10.1016/j.bmc.2014.04.013