2-([1,1'-Biphenyl]-4-yloxy)acetohydrazide

Base Information

• Chemical Name: 2-([1,1'-Biphenyl]-4-yloxy)acetohydrazide
• CAS No.: 84161-08-0
• Molecular Formula: C14H14 N2 O2
• Molecular Weight: 242.27316
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID40365766
• Nikkaji Number: J1.217.480B
• Wikidata: Q82150710
• Mol file: 84161-08-0.mol

Synonyms:84161-08-0;2-([1,1'-biphenyl]-4-yloxy)acetohydrazide;2-(4-phenylphenoxy)acetohydrazide;2-(biphenyl-4-yloxy)acetohydrazide;(Biphenyl-4-yloxy)-acetic acid hydrazide;2-{[1,1'-BIPHENYL]-4-YLOXY}ACETOHYDRAZIDE;Oprea1_523163;Oprea1_710421;(4-Biphenylyloxy)acetohydrazide;DTXSID40365766;BBL015535;MFCD01365732;STK033404;AKOS000116267;SB86248;VS-04959;2-(1,1'-biphenyl-4-yloxy)acetohydrazide;EN300-03631;2-[([1,1'-Biphenyl]-4-yl)oxy]acetohydrazide;SR-01000032006;SR-01000032006-1;Z56823446

Chemical Property of 2-([1,1'-Biphenyl]-4-yloxy)acetohydrazide

Chemical Property:

• Vapor Pressure: 3.93E-10mmHg at 25°C
• Refractive Index: 1.591
• Boiling Point: 500.1°C at 760 mmHg
• Flash Point: 256.2°C
• PSA: 64.35000
• Density: 1.182g/cm³
• LogP: 2.81350
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 242.105527694
• Heavy Atom Count: 18
• Complexity: 257

Purity/Quality:

98%min ^*data from raw suppliers

2-([1,1'-Biphenyl]-4-yloxy)acetohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)OCC(=O)NN

Technology Process of 2-([1,1'-Biphenyl]-4-yloxy)acetohydrazide

There total 3 articles about 2-([1,1'-Biphenyl]-4-yloxy)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl 2-(biphenyl-4-yloxy)acetate (54334-74-6) → 2-(biphenyl-4-yloxy)acetic acid hydrazide (84161-08-0)

Guidance literature:

With hydrazine hydrate; In ethanol; Reflux;

DOI:10.1016/j.ejmech.2013.08.027

Reference yield: 64.0%

methyl 4-biphenyloxyacetate (54334-73-5) → 2-(biphenyl-4-yloxy)acetic acid hydrazide (84161-08-0)

Guidance literature:

With hydrazine hydrate; In methanol; for 16h; Reflux;

DOI:10.3390/antibiotics10040438

Reference yield:

4-Phenylphenol (92-69-3) → 2-(biphenyl-4-yloxy)acetic acid hydrazide (84161-08-0)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetone / 20 h / Heating

2: hydrzine hydrate / ethanol / 10 h / Heating

With potassium carbonate; hydrazine hydrate; In ethanol; acetone;

DOI:10.1002/jps.2600781206

upstream raw materials:

ethyl 2-(biphenyl-4-yloxy)acetate

4-Phenylphenol

methyl 4-biphenyloxyacetate

Downstream raw materials:

C₂₃H₂₃N₃O₂S

C₂₁H₁₈IN₃O₂S

N₁-[2-(biphenyl-4-yloxy)ethanoyl]-N₄-(2,4-dimethylphenyl)-thiosemicarbazide

C₂₂H₂₁N₃O₂S