1-(3-{2-[bis(4-fluorophenyl)methoxy]ethyl}-3,8-diazabicyclo[3.2.1]oct-8-yl)-3-pyridin-3-ylpropenone

Base Information

Chemical Name:1-(3-{2-[bis(4-fluorophenyl)methoxy]ethyl}-3,8-diazabicyclo[3.2.1]oct-8-yl)-3-pyridin-3-ylpropenone
CAS No.:321365-79-1
Molecular Formula:C₂₉H₂₉F₂N₃O₂
Molecular Weight:489.565
Hs Code.:

Synonyms:1-(3-{2-[bis(4-fluorophenyl)methoxy]ethyl}-3,8-diazabicyclo[3.2.1]oct-8-yl)-3-pyridin-3-ylpropenone

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Chemical Property of 1-(3-{2-[bis(4-fluorophenyl)methoxy]ethyl}-3,8-diazabicyclo[3.2.1]oct-8-yl)-3-pyridin-3-ylpropenone

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Technology Process of 1-(3-{2-[bis(4-fluorophenyl)methoxy]ethyl}-3,8-diazabicyclo[3.2.1]oct-8-yl)-3-pyridin-3-ylpropenone

There total 4 articles about 1-(3-{2-[bis(4-fluorophenyl)methoxy]ethyl}-3,8-diazabicyclo[3.2.1]oct-8-yl)-3-pyridin-3-ylpropenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19337-97-4,1126-74-5
trans-3-(3-pyridyl)acrylic acid

: 321365-72-4
3-{2-[bis(4-fluorophenyl)methoxy]ethyl}-3,8-diazabicyclo[3.2.1]octane

: 321365-79-1
1-(3-{2-[bis(4-fluorophenyl)methoxy]ethyl}-3,8-diazabicyclo[3.2.1]oct-8-yl)-3-pyridin-3-ylpropenone

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1021/jm000300r

Reference yield:

: 50366-31-9
2-[bis(4-fluorophenyl)methoxy]ethyl chloride

: 321365-79-1
1-(3-{2-[bis(4-fluorophenyl)methoxy]ethyl}-3,8-diazabicyclo[3.2.1]oct-8-yl)-3-pyridin-3-ylpropenone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 0.40 g / Et₃N; K₂CO₃ / toluene / 48 h / Heating

2.1: 2,2,2-trichloroethyl chloroformate; K₂CO₃ / toluene / Heating

2.2: Zn; AcOH / 20 °C

3.1: EDCI / CH₂Cl₂ / 20 °C

With potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 2,2,2-Trichloroethyl chloroformate; In dichloromethane; toluene;
DOI:10.1021/jm000300r

Reference yield:

: 17783-50-5
8-methyl-3,8-diazabicyclo<3.2.1>octane hydrochloride

: 321365-79-1
1-(3-{2-[bis(4-fluorophenyl)methoxy]ethyl}-3,8-diazabicyclo[3.2.1]oct-8-yl)-3-pyridin-3-ylpropenone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 0.40 g / Et₃N; K₂CO₃ / toluene / 48 h / Heating

2.1: 2,2,2-trichloroethyl chloroformate; K₂CO₃ / toluene / Heating

2.2: Zn; AcOH / 20 °C

3.1: EDCI / CH₂Cl₂ / 20 °C

With potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 2,2,2-Trichloroethyl chloroformate; In dichloromethane; toluene;
DOI:10.1021/jm000300r