(1R,4R,6S,7S)-2-oxa-5-azabicyclo[4.1.0]heptane-4,5,7-tricarboxylic acid 5-benzyl ester 7-t-butyl ester 4-methyl ester

Base Information

Chemical Name:(1R,4R,6S,7S)-2-oxa-5-azabicyclo[4.1.0]heptane-4,5,7-tricarboxylic acid 5-benzyl ester 7-t-butyl ester 4-methyl ester
CAS No.:1080662-28-7
Molecular Formula:C₂₀H₂₅NO₇
Molecular Weight:391.421
Hs Code.:

Synonyms:(1R,4R,6S,7S)-2-oxa-5-azabicyclo[4.1.0]heptane-4,5,7-tricarboxylic acid 5-benzyl ester 7-t-butyl ester 4-methyl ester

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Chemical Property of (1R,4R,6S,7S)-2-oxa-5-azabicyclo[4.1.0]heptane-4,5,7-tricarboxylic acid 5-benzyl ester 7-t-butyl ester 4-methyl ester

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Technology Process of (1R,4R,6S,7S)-2-oxa-5-azabicyclo[4.1.0]heptane-4,5,7-tricarboxylic acid 5-benzyl ester 7-t-butyl ester 4-methyl ester

There total 1 articles about (1R,4R,6S,7S)-2-oxa-5-azabicyclo[4.1.0]heptane-4,5,7-tricarboxylic acid 5-benzyl ester 7-t-butyl ester 4-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1080662-24-3
(R)-2,3-dihydro-[1,4]oxazine-3,4-dicarboxylic acid 4-benzyl ester 3-methyl ester

: 35059-50-8
t-butyl diazoacetate

: 1080662-29-8
(1S,4R,6R,7R)-2-oxa-5-azabicyclo[4.1.0]heptane-4,5,7-tricarboxylic acid 5-benzyl ester 7-t-butyl ester 4-methyl ester

: 1080662-28-7
(1R,4R,6S,7S)-2-oxa-5-azabicyclo[4.1.0]heptane-4,5,7-tricarboxylic acid 5-benzyl ester 7-t-butyl ester 4-methyl ester

Guidance literature:: (R)-2,3-dihydro-[1,4]oxazine-3,4-dicarboxylic acid 4-benzyl ester 3-methyl ester; With copper(II) bis(trifluoromethanesulfonate); 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]; phenylhydrazine; In dichloromethane; for 0.5h;

t-butyl diazoacetate; In dichloromethane; at 20 ℃; for 22h; optical yield given as %de;
DOI:10.1039/b808895k