{(S)-1-[(tert-Butyl-dimethyl-silanyloxy)-(5-methyl-[1,2,4]oxadiazol-3-yl)-methyl]-pentyl}-carbamic acid (S)-2-cyclohexyl-1-methyl-ethyl ester

Base Information

Chemical Name:{(S)-1-[(tert-Butyl-dimethyl-silanyloxy)-(5-methyl-[1,2,4]oxadiazol-3-yl)-methyl]-pentyl}-carbamic acid (S)-2-cyclohexyl-1-methyl-ethyl ester
CAS No.:865537-77-5
Molecular Formula:C₂₅H₄₇N₃O₄Si
Molecular Weight:481.751
Hs Code.:

Synonyms:{(S)-1-[(tert-Butyl-dimethyl-silanyloxy)-(5-methyl-[1,2,4]oxadiazol-3-yl)-methyl]-pentyl}-carbamic acid (S)-2-cyclohexyl-1-methyl-ethyl ester

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Chemical Property of {(S)-1-[(tert-Butyl-dimethyl-silanyloxy)-(5-methyl-[1,2,4]oxadiazol-3-yl)-methyl]-pentyl}-carbamic acid (S)-2-cyclohexyl-1-methyl-ethyl ester

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Technology Process of {(S)-1-[(tert-Butyl-dimethyl-silanyloxy)-(5-methyl-[1,2,4]oxadiazol-3-yl)-methyl]-pentyl}-carbamic acid (S)-2-cyclohexyl-1-methyl-ethyl ester

There total 10 articles about {(S)-1-[(tert-Butyl-dimethyl-silanyloxy)-(5-methyl-[1,2,4]oxadiazol-3-yl)-methyl]-pentyl}-carbamic acid (S)-2-cyclohexyl-1-methyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1517-68-6,14898-87-4
(S)-1-phenylpropan-2-ol

: 865537-77-5
{(S)-1-[(tert-Butyl-dimethyl-silanyloxy)-(5-methyl-[1,2,4]oxadiazol-3-yl)-methyl]-pentyl}-carbamic acid (S)-2-cyclohexyl-1-methyl-ethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 90 percent / H₂; Aliquat 336 / RhCl₃*H₂O

2: toluene; tetrahydrofuran / 0 - 20 °C

3: iPr₂NEt / toluene; tetrahydrofuran

4: 87 percent / LiOH / tetrahydrofuran

5: N-methylmorpholine / tetrahydrofuran

6: sodium borohydride / tetrahydrofuran

7: sulfur trioxide pyridine complex / CH₂Cl₂

8: 18-crown-6; KCN / CH₂Cl₂

9: hydroxylamine; sodium acetate

10: toluene / Heating

With 4-methyl-morpholine; potassium cyanide; lithium hydroxide; sodium tetrahydroborate; 18-crown-6 ether; hydrogen; hydroxylamine; sodium acetate; sulfur trioxide pyridine complex; Aliquat 336; N-ethyl-N,N-diisopropylamine; rhodium(III) chloride; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2005.05.091

Reference yield:

: 865537-75-3
(S)-2-((S)-2-Cyclohexyl-1-methyl-ethoxycarbonylamino)-hexanoic acid

: 865537-77-5
{(S)-1-[(tert-Butyl-dimethyl-silanyloxy)-(5-methyl-[1,2,4]oxadiazol-3-yl)-methyl]-pentyl}-carbamic acid (S)-2-cyclohexyl-1-methyl-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: N-methylmorpholine / tetrahydrofuran

2: sodium borohydride / tetrahydrofuran

3: sulfur trioxide pyridine complex / CH₂Cl₂

4: 18-crown-6; KCN / CH₂Cl₂

5: hydroxylamine; sodium acetate

6: toluene / Heating

With 4-methyl-morpholine; potassium cyanide; sodium tetrahydroborate; 18-crown-6 ether; hydroxylamine; sodium acetate; sulfur trioxide pyridine complex; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2005.05.091

Reference yield:

: 865537-43-5
(S)-2-((S)-2-Cyclohexyl-1-methyl-ethoxycarbonylamino)-hexanoic acid methyl ester

: 865537-77-5
{(S)-1-[(tert-Butyl-dimethyl-silanyloxy)-(5-methyl-[1,2,4]oxadiazol-3-yl)-methyl]-pentyl}-carbamic acid (S)-2-cyclohexyl-1-methyl-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 87 percent / LiOH / tetrahydrofuran

2: N-methylmorpholine / tetrahydrofuran

3: sodium borohydride / tetrahydrofuran

4: sulfur trioxide pyridine complex / CH₂Cl₂

5: 18-crown-6; KCN / CH₂Cl₂

6: hydroxylamine; sodium acetate

7: toluene / Heating

With 4-methyl-morpholine; potassium cyanide; lithium hydroxide; sodium tetrahydroborate; 18-crown-6 ether; hydroxylamine; sodium acetate; sulfur trioxide pyridine complex; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2005.05.091