tert-butyl (1-(3,4-dimethoxyphenyl)-3-hydroxypropyl)carbamate

Base Information

• Chemical Name: tert-butyl (1-(3,4-dimethoxyphenyl)-3-hydroxypropyl)carbamate
• CAS No.: 1184872-14-7
• Molecular Formula: C₁₆H₂₅NO₅
• Molecular Weight: 311.378
• Mol file: 1184872-14-7.mol

Synonyms:tert-butyl (1-(3,4-dimethoxyphenyl)-3-hydroxypropyl)carbamate

Chemical Property of tert-butyl (1-(3,4-dimethoxyphenyl)-3-hydroxypropyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (1-(3,4-dimethoxyphenyl)-3-hydroxypropyl)carbamate

There total 4 articles about tert-butyl (1-(3,4-dimethoxyphenyl)-3-hydroxypropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-amino-3-(3,4-dimethoxyphenyl)propan-1-ol (201408-35-7) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (1-(3,4-dimethoxyphenyl)-3-hydroxypropyl)carbamate (1184872-14-7)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; at 0 ℃; for 8h;

DOI:10.1016/j.tetlet.2009.06.025

Reference yield: 79.5%

methyl 3-((tert-butoxycarbonyl)amino)-3-(3,4-dimethoxyphenyl)propanoate (1378029-24-3) → tert-butyl (1-(3,4-dimethoxyphenyl)-3-hydroxypropyl)carbamate (1184872-14-7)

Guidance literature:

With diborane; In tetrahydrofuran; at 0 - 20 ℃; for 20h;

DOI:10.1039/c2cc31281f

Reference yield:

3-amino-3-(3,4-dimethoxyphenyl)propanoic acid (34840-85-2,54160-62-2,34841-09-3,54160-63-3) → tert-butyl (1-(3,4-dimethoxyphenyl)-3-hydroxypropyl)carbamate (1184872-14-7)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / 24 h / Reflux

2: triethylamine / dichloromethane / 24 h / 23 °C

3: diborane / tetrahydrofuran / 20 h / 0 - 20 °C

With toluene-4-sulfonic acid; triethylamine; diborane; In tetrahydrofuran; dichloromethane;

DOI:10.1039/c2cc31281f

upstream raw materials:

3-amino-3-(3,4-dimethoxyphenyl)propan-1-ol

di-tert-butyl dicarbonate

methyl 3-((tert-butoxycarbonyl)amino)-3-(3,4-dimethoxyphenyl)propanoate

3-amino-3-(3,4-dimethoxyphenyl)propanoic acid

Downstream raw materials:

C₂₃H₃₁NO₅