Ivacaftor-d18

Base Information

Chemical Name:Ivacaftor-d18
CAS No.:1413431-05-6
Molecular Formula:C₂₄H₂₈N₂O₃
Molecular Weight:410.355
Hs Code.:
Mol file:1413431-05-6.mol

Synonyms:N-(2,4-bis(1,1,1,3,3,3-d₆-2-(methyl-d₃)propan-2-yl)-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

Suppliers and Price of Ivacaftor-d18

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Ivacaftor-d18
2.5mg
$ 460.00

Total 9 raw suppliers

Chemical Property of Ivacaftor-d18

Chemical Property:

Purity/Quality:

95% by HPLC; 95% atom D ^*data from raw suppliers

Ivacaftor-d18 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Ivacaftor-d18 is used in the treatment of cystic fibrosis. Ivacaftor is used in the treatment of cystic fibrosis. This is the labeled analog.

Technology Process of Ivacaftor-d18

There total 6 articles about Ivacaftor-d18 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 3-amino-4,6-bis(1,1,1,3,3,3-d₆-2-(methyl-d₃)propan-2-yl)phenol

: 13721-01-2
4-oxo-1,4-dihydroquinoline-3-carboxylic acid

: 1413431-05-6
N-(2,4-bis(1,1,1,3,3,3-d₆-2-(methyl-d₃)propan-2-yl)-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 1246816-88-5
2-d-4,6-bis(1,1,1,3,3,3-d₆-2-(methyl-d₃)propan-2-yl)phenol

: 1413431-05-6
N-(2,4-bis(1,1,1,3,3,3-d₆-2-(methyl-d₃)propan-2-yl)-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap; triethylamine / dichloromethane / 15 h / 0 - 20 °C

2.1: sulfuric acid; nitric acid / 2 h / 20 °C

2.2: 2 h / 20 °C

3.1: ammonium formate; palladium 10% on activated carbon / ethanol / 2 h / Reflux

4.1: hydrogenchloride / isopropyl alcohol / 15 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C

With hydrogenchloride; dmap; sulfuric acid; palladium 10% on activated carbon; nitric acid; ammonium formate; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 80441-87-8
2,4,6-d₃-phenol-OD

: 1413431-05-6
N-(2,4-bis(1,1,1,3,3,3-d₆-2-(methyl-d₃)propan-2-yl)-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid-d2 / dichloromethane / 15 h / 20 °C

2.1: dmap; triethylamine / dichloromethane / 15 h / 0 - 20 °C

3.1: sulfuric acid; nitric acid / 2 h / 20 °C

3.2: 2 h / 20 °C

4.1: ammonium formate; palladium 10% on activated carbon / ethanol / 2 h / Reflux

5.1: hydrogenchloride / isopropyl alcohol / 15 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C

With hydrogenchloride; dmap; sulfuric acid; palladium 10% on activated carbon; nitric acid; ammonium formate; sulfuric acid-d2; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;