1,1'-[(1,1-Dimethylethyl)[[(1R)-1-methyl-2-propyn-1-yl]oxy]silylene]bis[benzene]

Base Information

• Chemical Name: 1,1'-[(1,1-Dimethylethyl)[[(1R)-1-methyl-2-propyn-1-yl]oxy]silylene]bis[benzene]
• CAS No.: 380893-75-4
• Molecular Formula: C₂₀H₂₄OSi
• Molecular Weight: 308.495
• DSSTox Substance ID: DTXSID501134144
• Mol file: 380893-75-4.mol

Synonyms:SCHEMBL12820837;SCHEMBL13907170;DTXSID501134144;1,1'-[(1,1-Dimethylethyl)[[(1R)-1-methyl-2-propyn-1-yl]oxy]silylene]bis[benzene];380893-75-4

Chemical Property of 1,1'-[(1,1-Dimethylethyl)[[(1R)-1-methyl-2-propyn-1-yl]oxy]silylene]bis[benzene]

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 308.159641919
• Heavy Atom Count: 22
• Complexity: 370

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C#C)O[Si](C1=CC=CC=C1)(C2=CC=CC=C2)C(C)(C)C
• Isomeric SMILES: C[C@H](C#C)O[Si](C1=CC=CC=C1)(C2=CC=CC=C2)C(C)(C)C

Technology Process of 1,1'-[(1,1-Dimethylethyl)[[(1R)-1-methyl-2-propyn-1-yl]oxy]silylene]bis[benzene]

There total 1 articles about 1,1'-[(1,1-Dimethylethyl)[[(1R)-1-methyl-2-propyn-1-yl]oxy]silylene]bis[benzene] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-(+)-3-butyn-2-ol (42969-65-3) + tert-butylchlorodiphenylsilane (58479-61-1) → (R)-(but-3-yn-2-yloxy)(tert-butyl)diphenylsilane (380893-75-4)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 20 ℃;

DOI:10.1021/jo901728b

Reference yield: 97.0%

(R)-(but-3-yn-2-yloxy)(tert-butyl)diphenylsilane (380893-75-4) → (3R)-1-bromo-3-[(tert-butyldiphenylsilyl)oxy]but-1-yne (1300116-84-0)

Guidance literature:

With N-Bromosuccinimide; silver nitrate; In acetone; at 20 ℃; for 12h; Darkness;

DOI:10.1002/chem.201003265

Reference yield: 93.0%

C16H20BrNO5 + (R)-(but-3-yn-2-yloxy)(tert-butyl)diphenylsilane (380893-75-4) → C36H43NO6Si

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine; triphenylphosphine; at 70 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201300200

upstream raw materials:

(R)-(+)-3-butyn-2-ol

tert-butylchlorodiphenylsilane

Downstream raw materials:

(12R,16R)-2,2-dimethylpropionic acid 16-(tert-butyldiphenylsilanyloxy)-12-hydroxyheptadec-14-ynyl ester

(3R)-1-bromo-3-[(tert-butyldiphenylsilyl)oxy]but-1-yne

N-benzyl-N-[(3R)-3-(tert-butyldiphenylsilyloxy)but-1-ynyl]-4-methylbenzenesulfonamide

(2S,3S,4S,5S,Z)-3,4-di(benzyloxy)-2-(benzyloxymethyl)-6-ethylidene-1-azabicyclo[3.2.0]heptan-7-one