(2R,3S)-4-benzyl-2-({1-[3,5-bis(trifluoromethyl)phenyl]-vinyl}oxy)-3-(4-fluorophenyl)morpholine

Base Information

• Chemical Name: (2R,3S)-4-benzyl-2-({1-[3,5-bis(trifluoromethyl)phenyl]-vinyl}oxy)-3-(4-fluorophenyl)morpholine
• CAS No.: 170729-77-8
• Molecular Formula: C₂₆H₂₀F₇NO₃
• Molecular Weight: 527.439
• Mol file: 170729-77-8.mol

Synonyms:(2R,3S)-4-benzyl-2-({1-[3,5-bis(trifluoromethyl)phenyl]-vinyl}oxy)-3-(4-fluorophenyl)morpholine

Chemical Property of (2R,3S)-4-benzyl-2-({1-[3,5-bis(trifluoromethyl)phenyl]-vinyl}oxy)-3-(4-fluorophenyl)morpholine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R,3S)-4-benzyl-2-({1-[3,5-bis(trifluoromethyl)phenyl]-vinyl}oxy)-3-(4-fluorophenyl)morpholine

There total 7 articles about (2R,3S)-4-benzyl-2-({1-[3,5-bis(trifluoromethyl)phenyl]-vinyl}oxy)-3-(4-fluorophenyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-benzyl-3-(R)-(p-fluorophenyl)morpholin-2-one (219821-32-6) → (2R,3S)-4-benzyl-2-({1-[3,5-bis(trifluoromethyl)phenyl]-vinyl}oxy)-3-(4-fluorophenyl)morpholine (170729-77-8)

Guidance literature:

Reference yield: 83.0%

3,5-bis(trifluoromethyl)phenyl carboxylic acid chloride (785-56-8) + N-benzyl-3-(R)-(p-fluorophenyl)morpholin-2-one (219821-32-6) → (2R,3S)-4-benzyl-2-({1-[3,5-bis(trifluoromethyl)phenyl]-vinyl}oxy)-3-(4-fluorophenyl)morpholine (170729-77-8)

Guidance literature:

In tetrahydrofuran; water;

Reference yield:

3,5-bis(trifluoromethyl)phenyl carboxylic acid chloride (785-56-8) + 4-benzyl-3-(4-fluorophenyl)morpholin-2-one (159706-87-3) → (2R,3S)-4-benzyl-2-({1-[3,5-bis(trifluoromethyl)phenyl]-vinyl}oxy)-3-(4-fluorophenyl)morpholine (170729-77-8)

Guidance literature:

4-benzyl-3-(4-fluorophenyl)morpholin-2-one; With L-Selectride; In tetrahydrofuran; at -80 - -70 ℃; for 2h;

3,5-bis(trifluoromethyl)phenyl carboxylic acid chloride; In tetrahydrofuran; at -80 - -70 ℃; for 1.83333h;

With acetic acid; In tetrahydrofuran; at 25 - 30 ℃;

upstream raw materials:

N-benzyl-3-(R)-(p-fluorophenyl)morpholin-2-one

3,5-bis(trifluoromethyl)phenyl carboxylic acid chloride

4-benzyl-3-(4-fluorophenyl)morpholin-2-one

C₁₇H₁₈FNO₂

Downstream raw materials:

C₂₆H₂₀F₇NO₃*ClH

C₂₆⁽¹⁴⁾CH₂₂F₇NO₂