(+/-)-2,5-diamino-6-chloro-4-<<5-(benzyloxy)-3-hydroxypent-1-yl>amino>pyrimidine

Base Information

• Chemical Name: (+/-)-2,5-diamino-6-chloro-4-<<5-(benzyloxy)-3-hydroxypent-1-yl>amino>pyrimidine
• CAS No.: 128631-58-3
• Molecular Formula: C₁₆H₂₂ClN₅O₂
• Molecular Weight: 351.836
• Mol file: 128631-58-3.mol

Synonyms:(+/-)-2,5-diamino-6-chloro-4-<<5-(benzyloxy)-3-hydroxypent-1-yl>amino>pyrimidine

Chemical Property of (+/-)-2,5-diamino-6-chloro-4-<<5-(benzyloxy)-3-hydroxypent-1-yl>amino>pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-2,5-diamino-6-chloro-4-<<5-(benzyloxy)-3-hydroxypent-1-yl>amino>pyrimidine

There total 5 articles about (+/-)-2,5-diamino-6-chloro-4-<<5-(benzyloxy)-3-hydroxypent-1-yl>amino>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2,5-diamino-4,6-dichloropyrimidine (55583-59-0) + (+/-)-1-amino-5-(benzyloxy)pentan-3-ol (128631-53-8) → (+/-)-2,5-diamino-6-chloro-4-<<5-(benzyloxy)-3-hydroxypent-1-yl>amino>pyrimidine (128631-58-3)

Guidance literature:

With triethylamine; In butan-1-ol; at 100 ℃; for 48h;

DOI:10.1021/jm00171a022

Reference yield:

4-benzyloxybut-1-ene (70388-33-9) → (+/-)-2,5-diamino-6-chloro-4-<<5-(benzyloxy)-3-hydroxypent-1-yl>amino>pyrimidine (128631-58-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 87 percent / m-chloroperbenzoic acid / CH₂Cl₂ / Ambient temperature

2: 95 percent / Et₂AlCl / hexane / Ambient temperature

3: 58 percent / LiAlH₄ / diethyl ether / 2 h / Ambient temperature

4: 72 percent / Et₃N / butan-1-ol / 48 h / 100 °C

With lithium aluminium tetrahydride; diethylaluminium chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; hexane; dichloromethane; butan-1-ol;

DOI:10.1021/jm00171a022

Reference yield:

(+/-)-5-(benzyloxy)-3-(trimethylsiloxy)pentanenitrile (128631-52-7) → (+/-)-2,5-diamino-6-chloro-4-<<5-(benzyloxy)-3-hydroxypent-1-yl>amino>pyrimidine (128631-58-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / LiAlH₄ / diethyl ether / 2 h / Ambient temperature

2: 72 percent / Et₃N / butan-1-ol / 48 h / 100 °C

With lithium aluminium tetrahydride; triethylamine; In diethyl ether; butan-1-ol;

DOI:10.1021/jm00171a022

upstream raw materials:

2,5-diamino-4,6-dichloropyrimidine

(+/-)-1-amino-5-(benzyloxy)pentan-3-ol

4-benzyloxybut-1-ene

(+/-)-5-(benzyloxy)-3-(trimethylsiloxy)pentanenitrile

Downstream raw materials:

(+/-)-9-<5-(benzyloxy)-3-hydroxypent-1-yl>guanine

(+/-)-9-(3,5-dihydroxypent-1-yl)guanine

(+/-)-2-amino-6-chloro-9-<5-(benzyloxy)-3-hydroxypent-1-yl>-9H-purine