C₁₅H₁₈FN₃O₅

Base Information

• Chemical Name: C₁₅H₁₈FN₃O₅
• CAS No.: 1355034-84-2
• Molecular Formula: C₁₅H₁₈FN₃O₅
• Molecular Weight: 339.323
• Mol file: 1355034-84-2.mol

Synonyms:C₁₅H₁₈FN₃O₅

Chemical Property of C₁₅H₁₈FN₃O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₈FN₃O₅

There total 8 articles about C₁₅H₁₈FN₃O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C23H26FN3O9 (1355034-83-1) → C15H18FN3O5 (1355034-84-2)

Guidance literature:

With methanol; sodium methylate; at 20 ℃; for 3h; pH=9;

DOI:10.1016/j.bmcl.2011.10.062

Reference yield:

2,3,4,6-tetra-O-benzyl-D-glucopyranoside (59531-24-7) → C15H18FN3O5 (1355034-84-2)

Guidance literature:

Multi-step reaction with 7 steps

1.1: acetic anhydride; dimethyl sulfoxide / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.33 h / -78 - 0 °C

2.2: 3.5 h / -78 °C

3.1: triethylsilane; boron trifluoride diethyl etherate / methanol; dichloromethane; acetonitrile / 4 h / -15 °C / Inert atmosphere

4.1: sodium hydroxide / methanol; dichloromethane / 2 h / 20 °C

5.1: boron trifluoride diethyl etherate / 0 - 20 °C

6.1: copper(II) sulfate; sodium L-ascorbate / dichloromethane; water / 20 °C

7.1: methanol; sodium methylate / 3 h / 20 °C / pH 9

With methanol; triethylsilane; n-butyllithium; boron trifluoride diethyl etherate; sodium methylate; acetic anhydride; copper(II) sulfate; dimethyl sulfoxide; sodium L-ascorbate; sodium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; water; acetonitrile;

DOI:10.1016/j.bmcl.2011.10.062

Reference yield:

(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-one (13096-62-3) → C15H18FN3O5 (1355034-84-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1.33 h / -78 - 0 °C

1.2: 3.5 h / -78 °C

2.1: triethylsilane; boron trifluoride diethyl etherate / methanol; dichloromethane; acetonitrile / 4 h / -15 °C / Inert atmosphere

3.1: sodium hydroxide / methanol; dichloromethane / 2 h / 20 °C

4.1: boron trifluoride diethyl etherate / 0 - 20 °C

5.1: copper(II) sulfate; sodium L-ascorbate / dichloromethane; water / 20 °C

6.1: methanol; sodium methylate / 3 h / 20 °C / pH 9

With methanol; triethylsilane; n-butyllithium; boron trifluoride diethyl etherate; sodium methylate; copper(II) sulfate; sodium L-ascorbate; sodium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; water; acetonitrile;

DOI:10.1016/j.bmcl.2011.10.062

upstream raw materials:

(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-one

C₂₃H₂₆FN₃O₉

2,3,4,6-tetra-O-benzyl-D-glucopyranoside

trimethyl(((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)ethynyl)silane

Refernces