(1R,2S)-ethyl 2-(6-butoxynaphthalene-2-sulfonamido)cyclohexanecarboxylate

Base Information

• Chemical Name: (1R,2S)-ethyl 2-(6-butoxynaphthalene-2-sulfonamido)cyclohexanecarboxylate
• CAS No.: 1312919-61-1
• Molecular Formula: C₂₃H₃₁NO₅S
• Molecular Weight: 433.569
• Mol file: 1312919-61-1.mol

Synonyms:(1R,2S)-ethyl 2-(6-butoxynaphthalene-2-sulfonamido)cyclohexanecarboxylate

Chemical Property of (1R,2S)-ethyl 2-(6-butoxynaphthalene-2-sulfonamido)cyclohexanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S)-ethyl 2-(6-butoxynaphthalene-2-sulfonamido)cyclohexanecarboxylate

There total 2 articles about (1R,2S)-ethyl 2-(6-butoxynaphthalene-2-sulfonamido)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

C14H15ClO3S (857088-63-2) + (1R,2S)-2-aminocyclohexanecarboxylic acid ethyl ester (192047-04-4) → (1R,2S)-ethyl 2-(6-butoxynaphthalene-2-sulfonamido)cyclohexanecarboxylate (1312919-61-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.04.011

Reference yield:

sodium 2-naphthol-6-sulfonate (135-76-2) → (1R,2S)-ethyl 2-(6-butoxynaphthalene-2-sulfonamido)cyclohexanecarboxylate (1312919-61-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium / ethanol / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

1.3: 0 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

With sodium; triethylamine; In ethanol; dichloromethane;

DOI:10.1016/j.ejmech.2011.04.011

Reference yield: 89.0%

(1R,2S)-ethyl 2-(6-butoxynaphthalene-2-sulfonamido)cyclohexanecarboxylate (1312919-61-1) → (1R,2S)-2-(6-butoxynaphthalene-2-sulfonamido)cyclohexanecarboxylic acid (1312919-79-1)

Guidance literature:

(1R,2S)-ethyl 2-(6-butoxynaphthalene-2-sulfonamido)cyclohexanecarboxylate; With sodium hydroxide; In 1,4-dioxane; at 20 ℃; Inert atmosphere;

With hydrogenchloride; In water; pH=2; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.04.011

upstream raw materials:

C₁₄H₁₅ClO₃S

(1R,2S)-2-aminocyclohexanecarboxylic acid ethyl ester

sodium 2-naphthol-6-sulfonate

Downstream raw materials:

(1R,2S)-2-(6-butoxynaphthalene-2-sulfonamido)cyclohexanecarboxylic acid