(2-((R)-tetrahydro-5-methylene-2H-pyran-2-yl)ethoxy)(tert-butyl)diphenylsilane

Base Information

Chemical Name:(2-((R)-tetrahydro-5-methylene-2H-pyran-2-yl)ethoxy)(tert-butyl)diphenylsilane
CAS No.:953804-90-5
Molecular Formula:C₂₄H₃₂O₂Si
Molecular Weight:380.602
Hs Code.:

Synonyms:(2-((R)-tetrahydro-5-methylene-2H-pyran-2-yl)ethoxy)(tert-butyl)diphenylsilane

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Chemical Property of (2-((R)-tetrahydro-5-methylene-2H-pyran-2-yl)ethoxy)(tert-butyl)diphenylsilane

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Technology Process of (2-((R)-tetrahydro-5-methylene-2H-pyran-2-yl)ethoxy)(tert-butyl)diphenylsilane

There total 4 articles about (2-((R)-tetrahydro-5-methylene-2H-pyran-2-yl)ethoxy)(tert-butyl)diphenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 953804-89-2
(R)-7-(tert-butyldiphenylsilyloxy)-2-methyleneheptane-1,5-diol

: 953804-90-5
(2-((R)-tetrahydro-5-methylene-2H-pyran-2-yl)ethoxy)(tert-butyl)diphenylsilane

Guidance literature:: With titanium(IV) isopropylate; 4 A molecular sieve; triphenylphosphine; palladium diacetate; In toluene; for 1.5h; Heating;
DOI:10.1021/ol701553j

Reference yield:

: 125975-53-3,147220-48-2,116996-54-4
(2S)-O-(tert-butyldiphenylsilyl)-1,2-epoxybutan-4-ol

: 953804-90-5
(2-((R)-tetrahydro-5-methylene-2H-pyran-2-yl)ethoxy)(tert-butyl)diphenylsilane

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi; TMEDA / diethyl ether / 25.5 h / -78 - 20 °C

1.2: MgBr₂ / diethyl ether / 0 - 20 °C

1.3: 79 percent / tetrahydrofuran; diethyl ether / 2 h / 20 °C

2.1: 86 percent / triphenylphosphine; Ti(Oi-Pr)4; molecular sieves 4 Angstroem / Pd(OAc)2 / toluene / 1.5 h / Heating

With titanium(IV) isopropylate; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; 4 A molecular sieve; triphenylphosphine; palladium diacetate; In diethyl ether; toluene;
DOI:10.1021/ol701553j

Reference yield:

: 135006-32-5
4-tert-butyldiphenylsilyloxy-1-butene

: 953804-90-5
(2-((R)-tetrahydro-5-methylene-2H-pyran-2-yl)ethoxy)(tert-butyl)diphenylsilane

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / m-CPBA / CH₂Cl₂ / 0 - 20 °C

2.1: 44 percent / (S,S)-salen-Co; acetic acid; water / tetrahydrofuran / 0 - 20 °C

3.1: n-BuLi; TMEDA / diethyl ether / 25.5 h / -78 - 20 °C

3.2: MgBr₂ / diethyl ether / 0 - 20 °C

3.3: 79 percent / tetrahydrofuran; diethyl ether / 2 h / 20 °C

4.1: 86 percent / triphenylphosphine; Ti(Oi-Pr)4; molecular sieves 4 Angstroem / Pd(OAc)2 / toluene / 1.5 h / Heating

With titanium(IV) isopropylate; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; 4 A molecular sieve; water; acetic acid; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; palladium diacetate; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;
DOI:10.1021/ol701553j