C₁₇H₁₆Cl₂FN₃S

Base Information

Chemical Name:C₁₇H₁₆Cl₂FN₃S
CAS No.:1374820-29-7
Molecular Formula:C₁₇H₁₆Cl₂FN₃S
Molecular Weight:384.305
Hs Code.:

C<sub>17</sub>H<sub>16</sub>Cl<sub>2</sub>FN<sub>3</sub>S

Synonyms:C₁₇H₁₆Cl₂FN₃S

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Chemical Property of C₁₇H₁₆Cl₂FN₃S

Chemical Property:

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Technology Process of C₁₇H₁₆Cl₂FN₃S

There total 6 articles about C₁₇H₁₆Cl₂FN₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 348-40-3
2-amino-6-fluoro-1,3-benzothiazole

: 1374820-29-7
C₁₇H₁₆Cl₂FN₃S

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrazine hydrochloride; hydrazine hydrate / ethylene glycol / 2 h / 140 °C

2.1: thionyl chloride / 2 h / 50 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 120 °C

4.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

5.1: sodium methylate / methanol / 0.17 h / 20 °C / pH 12

5.2: 1 h / 50 °C

6.1: sodium cyanoborohydride / methanol / 6 h / 50 °C

With thionyl chloride; hydrazine hydrochloride; sodium methylate; sodium cyanoborohydride; potassium carbonate; hydrazine hydrate; trifluoroacetic acid; In methanol; dichloromethane; ethylene glycol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.03.079

Reference yield:

: C₁₇H₁₄Cl₂FN₃S

: 1374820-29-7
C₁₇H₁₆Cl₂FN₃S

Guidance literature:: With sodium cyanoborohydride; In methanol; at 50 ℃; for 6h;
DOI:10.1016/j.bmcl.2012.03.079

Reference yield:

: 399-74-6
2-chloro-6-fluorobenzothiazole

: 1374820-29-7
C₁₇H₁₆Cl₂FN₃S

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 120 °C

2.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

3.1: sodium methylate / methanol / 0.17 h / 20 °C / pH 12

3.2: 1 h / 50 °C

4.1: sodium cyanoborohydride / methanol / 6 h / 50 °C

With sodium methylate; sodium cyanoborohydride; potassium carbonate; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.03.079