6-benzyloxy-N²-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-N⁸-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-9H-purine-2,8-diamine

Base Information

• Chemical Name: 6-benzyloxy-N²-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-N⁸-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-9H-purine-2,8-diamine
• CAS No.: 896719-53-2
• Molecular Formula: C₆₃H₇₅N₉O₆Si₂
• Molecular Weight: 1110.52
• Mol file: 896719-53-2.mol

Synonyms:6-benzyloxy-N²-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-N⁸-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-9H-purine-2,8-diamine

Chemical Property of 6-benzyloxy-N²-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-N⁸-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-9H-purine-2,8-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-benzyloxy-N²-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-N⁸-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-9H-purine-2,8-diamine

There total 1 articles about 6-benzyloxy-N²-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-N⁸-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-9H-purine-2,8-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine (105650-23-5) + O6-benzyl-8-bromo-3′,5′-O-bis(tert-butyldimethylsilyl)-N2-dimethoxytrityl-2′-deoxyguanosine (479408-23-6) → 6-benzyloxy-N2-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-N8-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-9H-purine-2,8-diamine (896719-53-2)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In dimethyl sulfoxide; at 100 ℃;

DOI:10.1021/tx050296s

Reference yield:

6-benzyloxy-N2-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-N8-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-9H-purine-2,8-diamine (896719-53-2) → 2-amino-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-ylamino)-1,9-dihydro-purin-6-one (915092-62-5)

Guidance literature:

Multi-step reaction with 2 steps

1: CCl₃COOH / methanol; CH₂Cl₂

2: H₂ / Pd / tetrahydrofuran

With hydrogen; trichloroacetic acid; palladium; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/tx050296s

Reference yield:

6-benzyloxy-N2-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-N8-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-9H-purine-2,8-diamine (896719-53-2) → N'-[9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-ylamino)-6-oxo-6,9-dihydro-1H-purin-2-yl]-N,N-dimethyl-formamidine

Guidance literature:

Multi-step reaction with 3 steps

1: CCl₃COOH / methanol; CH₂Cl₂

2: H₂ / Pd / tetrahydrofuran

3: 72 percent / dimethylformamide / 20 °C

With hydrogen; trichloroacetic acid; palladium; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/tx050296s

upstream raw materials:

2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine

O⁶-benzyl-8-bromo-3′,5′-O-bis(tert-butyldimethylsilyl)-N²-dimethoxytrityl-2′-deoxyguanosine

Downstream raw materials:

6-benzyloxy-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-N⁸-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)-9H-purine-2,8-diamine

C₆₈H₈₃N₉O₈Si₂

C₇₀H₈₁N₉O₆Si₂

2-amino-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-8-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-ylamino)-1,9-dihydro-purin-6-one