N⁶-(chloroacetyl)-2'-deoxy-5-O-[(4-methoxyphenyl)(diphenyl)methyl]-1-methyladenosine

Base Information

• Chemical Name: N⁶-(chloroacetyl)-2'-deoxy-5-O-[(4-methoxyphenyl)(diphenyl)methyl]-1-methyladenosine
• CAS No.: 945026-42-6
• Molecular Formula: C₃₃H₃₂ClN₅O₅
• Molecular Weight: 614.101

Synonyms:N⁶-(chloroacetyl)-2'-deoxy-5-O-[(4-methoxyphenyl)(diphenyl)methyl]-1-methyladenosine

Chemical Property of N⁶-(chloroacetyl)-2'-deoxy-5-O-[(4-methoxyphenyl)(diphenyl)methyl]-1-methyladenosine

Chemical Property:

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Technology Process of N⁶-(chloroacetyl)-2'-deoxy-5-O-[(4-methoxyphenyl)(diphenyl)methyl]-1-methyladenosine

There total 3 articles about N⁶-(chloroacetyl)-2'-deoxy-5-O-[(4-methoxyphenyl)(diphenyl)methyl]-1-methyladenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2'-deoxy-5-O-[(4-methoxyphenyl)(diphenyl)methyl]-1-methyladenosine (945026-39-1) + Chloroacetic anhydride (541-88-8) → N6-(chloroacetyl)-2'-deoxy-5-O-[(4-methoxyphenyl)(diphenyl)methyl]-1-methyladenosine (945026-42-6)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1002/hlca.200790093

Reference yield:

2'-deoxy-5-O-[(4-methoxyphenyl)(diphenyl)methyl]adenosine (51600-10-3) → N6-(chloroacetyl)-2'-deoxy-5-O-[(4-methoxyphenyl)(diphenyl)methyl]-1-methyladenosine (945026-42-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / N,N-dimethyl-acetamide / 16 h / 20 °C

2: 78 percent / pyridine / CH₂Cl₂ / 1 h / 0 °C

With pyridine; In dichloromethane; N,N-dimethyl acetamide;

DOI:10.1002/hlca.200790093

Reference yield:

mono-4-methoxytrityl chloride (14470-28-1) → N6-(chloroacetyl)-2'-deoxy-5-O-[(4-methoxyphenyl)(diphenyl)methyl]-1-methyladenosine (945026-42-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 67 percent / pyridine / 16 h / 20 °C

2: 72 percent / N,N-dimethyl-acetamide / 16 h / 20 °C

3: 78 percent / pyridine / CH₂Cl₂ / 1 h / 0 °C

With pyridine; In dichloromethane; N,N-dimethyl acetamide;

DOI:10.1002/hlca.200790093

upstream raw materials:

2'-deoxy-5-O-[(4-methoxyphenyl)(diphenyl)methyl]-1-methyladenosine

Chloroacetic anhydride

2'-deoxy-5-O-[(4-methoxyphenyl)(diphenyl)methyl]adenosine

mono-4-methoxytrityl chloride

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