Technology Process of N-(3-(2-(hydroxymethyl)phenyl)but-3-enyl)-4-methylbenzenesulfonamide
There total 14 articles about N-(3-(2-(hydroxymethyl)phenyl)but-3-enyl)-4-methylbenzenesulfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine; hydrogen fluoride;
In
tetrahydrofuran;
at 20 ℃;
for 12h;
DOI:10.1002/ejoc.201402157
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 1H-imidazole / dichloromethane / 1.17 h / 0 - 20 °C
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 3 h / -78 - 20 °C
2.2: 2 h / 25 °C
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / 0 °C
3.2: 23 °C
4.1: camphor-10-sulfonic acid / methanol / 0 °C
5.1: triethylamine; dmap / dichloromethane / 1 h / 0 - 20 °C
6.1: sodium azide / N,N-dimethyl-formamide / 8 h / 80 °C
7.1: triphenylphosphine / tetrahydrofuran; water / 12 h / 20 °C
8.1: triethylamine; dmap / dichloromethane / 3 h / 0 - 20 °C
9.1: pyridine; hydrogen fluoride / tetrahydrofuran / 12 h / 20 °C
With
pyridine; 1H-imidazole; dmap; sodium azide; oxalyl dichloride; camphor-10-sulfonic acid; hydrogen fluoride; dimethyl sulfoxide; triethylamine; triphenylphosphine; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1002/ejoc.201402157
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / 0 °C
1.2: 23 °C
2.1: camphor-10-sulfonic acid / methanol / 0 °C
3.1: triethylamine; dmap / dichloromethane / 1 h / 0 - 20 °C
4.1: sodium azide / N,N-dimethyl-formamide / 8 h / 80 °C
5.1: triphenylphosphine / tetrahydrofuran; water / 12 h / 20 °C
6.1: triethylamine; dmap / dichloromethane / 3 h / 0 - 20 °C
7.1: pyridine; hydrogen fluoride / tetrahydrofuran / 12 h / 20 °C
With
pyridine; dmap; sodium azide; camphor-10-sulfonic acid; hydrogen fluoride; triethylamine; triphenylphosphine; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201402157
