4-methylphenyl-[3-(2-methylthiophenyl)-1-trifluoromethylprop-2-ynylidene]amine

Base Information

• Chemical Name: 4-methylphenyl-[3-(2-methylthiophenyl)-1-trifluoromethylprop-2-ynylidene]amine
• CAS No.: 1373128-05-2
• Molecular Formula: C₁₈H₁₄F₃NS
• Molecular Weight: 333.377
• Mol file: 1373128-05-2.mol

Synonyms:4-methylphenyl-[3-(2-methylthiophenyl)-1-trifluoromethylprop-2-ynylidene]amine

Chemical Property of 4-methylphenyl-[3-(2-methylthiophenyl)-1-trifluoromethylprop-2-ynylidene]amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methylphenyl-[3-(2-methylthiophenyl)-1-trifluoromethylprop-2-ynylidene]amine

There total 1 articles about 4-methylphenyl-[3-(2-methylthiophenyl)-1-trifluoromethylprop-2-ynylidene]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

<(o-methylthio)phenyl>acetylene (78905-08-5) + 2,2,2-Trifluoro-N-p-tolyl-acetimidoyl iodide (134481-25-7) → 4-methylphenyl-[3-(2-methylthiophenyl)-1-trifluoromethylprop-2-ynylidene]amine (1373128-05-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.jorganchem.2012.02.009

Reference yield:

4-methylphenyl-[3-(2-methylthiophenyl)-1-trifluoromethylprop-2-ynylidene]amine (1373128-05-2) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → C21H16F3NO2S

Guidance literature:

With bis(benzonitrile)palladium(II) dichloride; p-benzoquinone; lithium chloride; In tetrahydrofuran; at 70 ℃; for 5h; stereoselective reaction; Inert atmosphere;

DOI:10.1016/j.jorganchem.2012.02.009

Reference yield:

4-methylphenyl-[3-(2-methylthiophenyl)-1-trifluoromethylprop-2-ynylidene]amine (1373128-05-2) → (E)-methyl 3-(2-(2,2,2-trifluoro-1-p-tolylethylamino)benzo[b]thiophen-3-yl)acrylate (1373127-99-1)

Guidance literature:

Multi-step reaction with 2 steps

1: bis(benzonitrile)palladium(II) dichloride; p-benzoquinone; lithium chloride / tetrahydrofuran / 5 h / 70 °C / Inert atmosphere

2: sodium cyanoborohydride / methanol; acetic acid / 1.25 h / 0 °C / Inert atmosphere

With bis(benzonitrile)palladium(II) dichloride; sodium cyanoborohydride; p-benzoquinone; lithium chloride; In tetrahydrofuran; methanol; acetic acid;

DOI:10.1016/j.jorganchem.2012.02.009

upstream raw materials:

<(o-methylthio)phenyl>acetylene

2,2,2-Trifluoro-N-p-tolyl-acetimidoyl iodide

Downstream raw materials:

(E)-methyl 3-(2-(2,2,2-trifluoro-1-p-tolylethylamino)benzo[b]thiophen-3-yl)acrylate