2-(4-Chlorphenyl)-2-cyclopropyl-2-hydroxy-N-methyl-acetohydroxamsaeure

Base Information

• Chemical Name: 2-(4-Chlorphenyl)-2-cyclopropyl-2-hydroxy-N-methyl-acetohydroxamsaeure
• CAS No.: 129168-35-0
• Molecular Formula: C₁₂H₁₄ClNO₃
• Molecular Weight: 255.701
• Mol file: 129168-35-0.mol

Synonyms:2-(4-Chlorphenyl)-2-cyclopropyl-2-hydroxy-N-methyl-acetohydroxamsaeure

Chemical Property of 2-(4-Chlorphenyl)-2-cyclopropyl-2-hydroxy-N-methyl-acetohydroxamsaeure

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(4-Chlorphenyl)-2-cyclopropyl-2-hydroxy-N-methyl-acetohydroxamsaeure

There total 1 articles about 2-(4-Chlorphenyl)-2-cyclopropyl-2-hydroxy-N-methyl-acetohydroxamsaeure which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4-Chlor-N-methyl-phenylglyoxylohydroxamsaeure (117177-62-5) → 2-(4-Chlorphenyl)-2-cyclopropyl-2-hydroxy-N-methyl-acetohydroxamsaeure (129168-35-0)

Guidance literature:

In diethyl ether; for 2h; Heating;

DOI:10.1002/ardp.19903230310

Reference yield: 89.0%

2-(4-Chlorphenyl)-2-cyclopropyl-2-hydroxy-N-methyl-acetohydroxamsaeure (129168-35-0) → 4-(4-Chlorphenyl)-4-cyclopropyl-2-methyl-1,2-oxazetidin-3-on (131894-42-3)

Guidance literature:

With 2-hydroxypyridin; thionyl chloride; triethylamine; In dichloromethane; for 0.166667h; Ambient temperature;

DOI:10.1002/ardp.19903231206

Reference yield:

2-(4-Chlorphenyl)-2-cyclopropyl-2-hydroxy-N-methyl-acetohydroxamsaeure (129168-35-0) + 1,1'-carbonyldiimidazole (530-62-1) → 4-(4-Chloro-phenyl)-4-cyclopropyl-2-methyl-[1,5,2]dioxazinane-3,6-dione

Guidance literature:

In dichloromethane; for 4h; Ambient temperature;

DOI:10.1002/ardp.19903231206

upstream raw materials:

4-Chlor-N-methyl-phenylglyoxylohydroxamsaeure

Downstream raw materials:

4-(4-Chlorphenyl)-4-cyclopropyl-2-methyl-1,2-oxazetidin-3-on