ethyl 4-ethyl-2-methyl-6-[[2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]acetyl]amino]pyrimidine-5-carboxylate

Base Information

Chemical Name:ethyl 4-ethyl-2-methyl-6-[[2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]acetyl]amino]pyrimidine-5-carboxylate
CAS No.:1448545-15-0
Molecular Formula:C₂₄H₂₃F₃N₄O₄
Molecular Weight:488.466
Hs Code.:

Synonyms:ethyl 4-ethyl-2-methyl-6-[[2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]acetyl]amino]pyrimidine-5-carboxylate

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Chemical Property of ethyl 4-ethyl-2-methyl-6-[[2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]acetyl]amino]pyrimidine-5-carboxylate

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Technology Process of ethyl 4-ethyl-2-methyl-6-[[2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]acetyl]amino]pyrimidine-5-carboxylate

There total 5 articles about ethyl 4-ethyl-2-methyl-6-[[2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]acetyl]amino]pyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1448545-45-6
2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]acetamide

: 157981-63-0
ethyl 4-chloro-6-ethyl-2-methyl-pyrimidine-5-carboxylate

: 1448545-15-0
ethyl 4-ethyl-2-methyl-6-[[2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]acetyl]amino]pyrimidine-5-carboxylate

Guidance literature:: With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; at 80 ℃; for 2h; Inert atmosphere; Microwave irradiation;

Reference yield: 19.0%

: 157981-63-0
ethyl 4-chloro-6-ethyl-2-methyl-pyrimidine-5-carboxylate

: 1448541-32-9
2-[3-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]acetamide

: 1448545-15-0
ethyl 4-ethyl-2-methyl-6-[[2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]acetyl]amino]pyrimidine-5-carboxylate

Guidance literature:: With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; at 80 ℃; for 2h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester

: 1448545-15-0
ethyl 4-ethyl-2-methyl-6-[[2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]acetyl]amino]pyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; potassium iodide / 1-methyl-pyrrolidin-2-one / 0.33 h / 20 °C

1.2: 5 h / 130 °C

2.1: sodium cyanide; ammonia / methanol / 51 h / 20 - 35 °C

3.1: caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran / 2 h / 80 °C / Inert atmosphere; Microwave irradiation

With sodium cyanide; ammonia; palladium diacetate; potassium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium iodide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol;