2-(4-Dimethylamino-2,5-difluoro-benzylsulfanyl)-N-pyridin-4-yl-nicotinamide

Base Information

Chemical Name:2-(4-Dimethylamino-2,5-difluoro-benzylsulfanyl)-N-pyridin-4-yl-nicotinamide
CAS No.:181823-14-3
Molecular Formula:C₂₀H₁₈F₂N₄OS
Molecular Weight:400.452
Hs Code.:

Synonyms:2-(4-Dimethylamino-2,5-difluoro-benzylsulfanyl)-N-pyridin-4-yl-nicotinamide

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Chemical Property of 2-(4-Dimethylamino-2,5-difluoro-benzylsulfanyl)-N-pyridin-4-yl-nicotinamide

Chemical Property:

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Technology Process of 2-(4-Dimethylamino-2,5-difluoro-benzylsulfanyl)-N-pyridin-4-yl-nicotinamide

There total 4 articles about 2-(4-Dimethylamino-2,5-difluoro-benzylsulfanyl)-N-pyridin-4-yl-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 504-24-5
4-aminopyridine

: 181824-00-0
2-(4-Dimethylamino-2,5-difluoro-benzylsulfanyl)-nicotinic acid

: 181823-14-3
2-(4-Dimethylamino-2,5-difluoro-benzylsulfanyl)-N-pyridin-4-yl-nicotinamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 3h; Ambient temperature;

Reference yield:

: 446-17-3
2,4,5-trifluorobenzoic acid

: 181823-14-3
2-(4-Dimethylamino-2,5-difluoro-benzylsulfanyl)-N-pyridin-4-yl-nicotinamide

Guidance literature:: Multi-step reaction with 7 steps

1: (COCl)2 / dioxane / 0.5 h / Ambient temperature

2: tetrahydrofuran / 0.5 h / Ambient temperature

3: 93 percent / ethanol / 3 h / Heating

4: Na(MeO)2AlH₂ / toluene / 30 min, 5 deg C then 3 h, room t.

5: SOCl₂ / toluene / 0.5 h / Ambient temperature

6: 78 percent / Et₃N / dimethylformamide / 2 h / Ambient temperature

7: 72 percent / Et₃N=C=N(CH₂)3NMe₂*HCl / CH₂Cl₂ / 3 h / Ambient temperature

With thionyl chloride; oxalyl dichloride; Na[AlH₂(OMe)2]; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 181824-36-2
4-Dimethylamino-2,5-difluoro-benzoic acid methyl ester

: 181823-14-3
2-(4-Dimethylamino-2,5-difluoro-benzylsulfanyl)-N-pyridin-4-yl-nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1: Na(MeO)2AlH₂ / toluene / 30 min, 5 deg C then 3 h, room t.

2: SOCl₂ / toluene / 0.5 h / Ambient temperature

3: 78 percent / Et₃N / dimethylformamide / 2 h / Ambient temperature

4: 72 percent / Et₃N=C=N(CH₂)3NMe₂*HCl / CH₂Cl₂ / 3 h / Ambient temperature

With thionyl chloride; Na[AlH₂(OMe)2]; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;