tert-butyl 3-(5-(2-methyl-5-(3-(trifluoromethyl)benzamido)benzamido)pyrimidin-2-ylamino)-phenylcarbamate

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Chemical Name:tert-butyl 3-(5-(2-methyl-5-(3-(trifluoromethyl)benzamido)benzamido)pyrimidin-2-ylamino)-phenylcarbamate
CAS No.:1431727-39-7
Molecular Formula:C₃₁H₂₉F₃N₆O₄
Molecular Weight:606.604
Hs Code.:

Synonyms:tert-butyl 3-(5-(2-methyl-5-(3-(trifluoromethyl)benzamido)benzamido)pyrimidin-2-ylamino)-phenylcarbamate

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Chemical Property of tert-butyl 3-(5-(2-methyl-5-(3-(trifluoromethyl)benzamido)benzamido)pyrimidin-2-ylamino)-phenylcarbamate

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Technology Process of tert-butyl 3-(5-(2-methyl-5-(3-(trifluoromethyl)benzamido)benzamido)pyrimidin-2-ylamino)-phenylcarbamate

There total 10 articles about tert-butyl 3-(5-(2-methyl-5-(3-(trifluoromethyl)benzamido)benzamido)pyrimidin-2-ylamino)-phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 896160-43-3
2-methyl-5-(3-(trifluoromethyl)benzamido)benzoic acid

: 1431727-38-6
tert-butyl 3-(5-aminopyrimidin-2-ylamino)phenylcarbamate

: 1431727-39-7
tert-butyl 3-(5-(2-methyl-5-(3-(trifluoromethyl)benzamido)benzamido)pyrimidin-2-ylamino)-phenylcarbamate

Guidance literature:: tert-butyl 3-(5-aminopyrimidin-2-ylamino)phenylcarbamate; With thionyl chloride; at 80 ℃; for 1h;

2-methyl-5-(3-(trifluoromethyl)benzamido)benzoic acid; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: C₁₅H₁₈ClN₅O₂

: 1431727-39-7
tert-butyl 3-(5-(2-methyl-5-(3-(trifluoromethyl)benzamido)benzamido)pyrimidin-2-ylamino)-phenylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 68621-88-5
(3-aminophenyl)carbamic acid tert-butyl ester

: 1431727-39-7
tert-butyl 3-(5-(2-methyl-5-(3-(trifluoromethyl)benzamido)benzamido)pyrimidin-2-ylamino)-phenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile; water / 3 h / 20 °C

2: 5%-palladium/activated carbon; hydrogen / methanol / 20 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With 5%-palladium/activated carbon; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm4017762