(3R)-7-Amino-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Base Information

Chemical Name:(3R)-7-Amino-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
CAS No.:754170-16-6
Molecular Formula:C₁₀H₁₂N₂O₂
Molecular Weight:192.217
Hs Code.:
DSSTox Substance ID:DTXSID40593360
Mol file:754170-16-6.mol

Synonyms:754170-16-6;(3R)-7-Amino-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid;(R)-7-amino-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid;DTXSID40593360;3-Isoquinolinecarboxylicacid,7-amino-1,2,3,4-tetrahydro-,(3R)-(9CI)

Suppliers and Price of (3R)-7-Amino-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of (3R)-7-Amino-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Chemical Property:

Boiling Point:455.7±45.0 °C(Predicted)
PKA:2.04±0.20(Predicted)
PSA：75.35000
Density:1.309±0.06 g/cm3(Predicted)
LogP:1.27770
XLogP3:-2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:192.089877630
Heavy Atom Count:14
Complexity:232

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(NCC2=C1C=CC(=C2)N)C(=O)O
Isomeric SMILES:C1[C@@H](NCC2=C1C=CC(=C2)N)C(=O)O

Technology Process of (3R)-7-Amino-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

There total 2 articles about (3R)-7-Amino-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 77141-07-2,233272-36-1
(S)-7-nitro-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

: 236429-63-3,754170-16-6,756803-94-8
7-amino-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 2h;
DOI:10.1016/S0040-4039(01)00491-9

Reference yield:

: 74163-81-8
L-Tic-OH

: 236429-63-3,754170-16-6,756803-94-8
7-amino-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / HNO₃; H₂SO₄ / 3.5 h / -10 °C

2: 98 percent / H₂ / Pd/C / methanol / 2 h / 20 °C

With sulfuric acid; hydrogen; nitric acid; palladium on activated charcoal; In methanol;
DOI:10.1016/S0040-4039(01)00491-9