8-cyclohexyl-N₅-((dimethylamino)sulfonyl)-11-methoxy-N₁a-methyl-N₁a-(1-methyl-3-pyrrolidinyl)-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxamide

Base Information

• Chemical Name: 8-cyclohexyl-N₅-((dimethylamino)sulfonyl)-11-methoxy-N₁a-methyl-N₁a-(1-methyl-3-pyrrolidinyl)-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxamide
• CAS No.: 1058130-45-2
• Molecular Formula: C₃₅H₄₅N₅O₅S
• Molecular Weight: 647.839

Synonyms:8-cyclohexyl-N₅-((dimethylamino)sulfonyl)-11-methoxy-N₁a-methyl-N₁a-(1-methyl-3-pyrrolidinyl)-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxamide

Chemical Property of 8-cyclohexyl-N₅-((dimethylamino)sulfonyl)-11-methoxy-N₁a-methyl-N₁a-(1-methyl-3-pyrrolidinyl)-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxamide

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Technology Process of 8-cyclohexyl-N₅-((dimethylamino)sulfonyl)-11-methoxy-N₁a-methyl-N₁a-(1-methyl-3-pyrrolidinyl)-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxamide

There total 1 articles about 8-cyclohexyl-N₅-((dimethylamino)sulfonyl)-11-methoxy-N₁a-methyl-N₁a-(1-methyl-3-pyrrolidinyl)-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid, 8-cyclohexyl-5-[[[(dimethylamino)sulfonyl]amino]carbonyl]-1,12b-dihydro-11-methoxy-, (+/-)- (959983-22-3) + N,1-dimethylpyrrolidin-3-amine (64021-83-6,792970-21-9) → 8-cyclohexyl-N5-((dimethylamino)sulfonyl)-11-methoxy-N1a-methyl-N1a-(1-methyl-3-pyrrolidinyl)-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxamide (1058130-45-2)

Guidance literature:

With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

upstream raw materials:

cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid, 8-cyclohexyl-5-[[[(dimethylamino)sulfonyl]amino]carbonyl]-1,12b-dihydro-11-methoxy-, (+/-)-

N,1-dimethylpyrrolidin-3-amine

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