Technology Process of (2E,4E,6Z,8E)-7-Methyl-3-phenethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid ethyl ester
There total 4 articles about (2E,4E,6Z,8E)-7-Methyl-3-phenethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(3Z,5E)-4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,5-hexadien-1-yne;
With
nBu3Sn(nBu)Cu(CN)Li2;
In
tetrahydrofuran;
at -78 ℃;
ethyl (E)-5-phenyl-3-(trifluoromethylsulfonyloxy)pent-2-enoate;
With
triphenyl-arsane;
tris(dibenzylideneacetone)dipalladium (0);
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 20 ℃;
DOI:10.1055/s-2001-14908
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: NaN(TMS)2
2.1: Bu3SnCu(Bu)CNLi2 / tetrahydrofuran / -78 °C
2.2: 57 percent / Ph3As / Pd2(dba)3 / tetrahydrofuran; dimethylformamide / 20 °C
With
nBu3Sn(nBu)Cu(CN)Li2; sodium hexamethyldisilazane;
In
tetrahydrofuran;
1.1: Wittig reaction / 3.2: Stille reaction;
DOI:10.1055/s-2001-14908
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: NaH; n-BuLi / tetrahydrofuran / -78 °C
1.2: 33 percent / tetrahydrofuran / 0 °C
2.1: Bu3SnCu(Bu)CNLi2 / tetrahydrofuran / -78 °C
2.2: 57 percent / Ph3As / Pd2(dba)3 / tetrahydrofuran; dimethylformamide / 20 °C
With
n-butyllithium; nBu3Sn(nBu)Cu(CN)Li2; sodium hydride;
In
tetrahydrofuran;
2.2: Stille reaction;
DOI:10.1055/s-2001-14908