3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-methoxycarbonyldocetaxel

Base Information

Chemical Name:3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-methoxycarbonyldocetaxel
CAS No.:926306-88-9
Molecular Formula:C₄₁H₅₀ClF₂NO₁₆
Molecular Weight:886.295
Hs Code.:

Synonyms:3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-methoxycarbonyldocetaxel

Suppliers and Price of 3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-methoxycarbonyldocetaxel

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-methoxycarbonyldocetaxel

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-methoxycarbonyldocetaxel

There total 8 articles about 3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-methoxycarbonyldocetaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₅₆H₈₄ClF₂NO₁₆Si₂

: 926306-88-9
3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-methoxycarbonyldocetaxel

Guidance literature:: With pyridine; hydrogen fluoride; In acetonitrile; at 0 - 20 ℃;
DOI:10.1016/j.jfluchem.2012.07.007

Reference yield:

: C₃₅H₄₉ClO₁₀Si

: 926306-88-9
3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-methoxycarbonyldocetaxel

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane / tetrahydrofuran

2: lithium hexamethyldisilazane / tetrahydrofuran / -40 °C

3: pyridine; hydrogen fluoride / acetonitrile / 0 - 20 °C

With pyridine; hydrogen fluoride; lithium hexamethyldisilazane; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.jfluchem.2012.07.007

Reference yield:

: 926306-99-2
(3R,4S)-1-(4-methoxyphenyl)-3-triisopropylsiloxy-4-(2,2-difluorovinyl)azetidin-2-one

: 926306-88-9
3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-methoxycarbonyldocetaxel

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium cerium (IV) nitrate; water / acetonitrile / 2 h / -10 °C

2: triethylamine; dmap / dichloromethane / 18 h / 20 °C

3: lithium hexamethyldisilazane / tetrahydrofuran / -40 °C

4: pyridine; hydrogen fluoride / acetonitrile / 0 - 20 °C

With pyridine; dmap; ammonium cerium (IV) nitrate; hydrogen fluoride; water; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/j.jfluchem.2012.07.007