9-[5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-L-erythro-pentofuranosyl]hypoxanthine

Base Information

Chemical Name:9-[5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-L-erythro-pentofuranosyl]hypoxanthine
CAS No.:259261-19-3
Molecular Formula:C₂₆H₃₀N₄O₃Si
Molecular Weight:474.635
Hs Code.:

Synonyms:9-[5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-L-erythro-pentofuranosyl]hypoxanthine

Suppliers and Price of 9-[5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-L-erythro-pentofuranosyl]hypoxanthine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9-[5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-L-erythro-pentofuranosyl]hypoxanthine

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Technology Process of 9-[5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-L-erythro-pentofuranosyl]hypoxanthine

There total 22 articles about 9-[5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-L-erythro-pentofuranosyl]hypoxanthine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.4%

: 259256-56-9
9-[5-O-(tert-butyldiphenylsilyl)-3-deoxy-2-Se-phenyl-2-seleno-β-L-erythro-pentofuranosyl]hypoxanthine

: 259261-19-3
9-[5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-L-erythro-pentofuranosyl]hypoxanthine

Guidance literature:: With triethyl borane; tri-n-butyl-tin hydride; In benzene; at 20 ℃; for 1h;
DOI:10.1080/07328319908044642

Reference yield:

: (R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-trimethylsilanyloxy-2,3-dihydro-furan

: 259261-19-3
9-[(2S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-1,9-dihydro-purin-6-one

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / -78 °C

2: DIBAL-H / tetrahydrofuran / -78 °C

3: DMAP / CH₂Cl₂ / 0 °C

4: 73 percent / TMSOTf / 1,2-dichloro-ethane / -22 °C

5: 96 percent / HSC₂H₄OH, NaOMe / methanol / Heating

6: Bu₃SnH, Et₃B / benzene / Ambient temperature

With dmap; triethyl borane; trimethylsilyl trifluoromethanesulfonate; tri-n-butyl-tin hydride; sodium methylate; diisobutylaluminium hydride; 2-hydroxyethanethiol; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; benzene;
DOI:10.1016/0960-894X(96)00293-4