2-(2,5-dihydro-1H-pyrrole-1-carbonyloxy)propane-1,3-diyl dicyclohexanecarboxylate

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Chemical Name:2-(2,5-dihydro-1H-pyrrole-1-carbonyloxy)propane-1,3-diyl dicyclohexanecarboxylate
CAS No.:1332880-36-0
Molecular Formula:C₂₂H₃₃NO₆
Molecular Weight:407.507
Hs Code.:

Synonyms:2-(2,5-dihydro-1H-pyrrole-1-carbonyloxy)propane-1,3-diyl dicyclohexanecarboxylate

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Chemical Property of 2-(2,5-dihydro-1H-pyrrole-1-carbonyloxy)propane-1,3-diyl dicyclohexanecarboxylate

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Technology Process of 2-(2,5-dihydro-1H-pyrrole-1-carbonyloxy)propane-1,3-diyl dicyclohexanecarboxylate

There total 3 articles about 2-(2,5-dihydro-1H-pyrrole-1-carbonyloxy)propane-1,3-diyl dicyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1332880-27-9
1,3-dihydroxypropan-2-yl 2,5-dihydro-1H-pyrrole-1-carboxylate

: 22651-87-2
cyclohexanecarboxylic acid anhydride

: 1332880-31-5
(R)-1-(cyclohexanecarbonyloxy)-3-hydroxypropan-2-yl 2,5-dihydro-1H-pyrrole-1-carboxylate

: 1332880-36-0
2-(2,5-dihydro-1H-pyrrole-1-carbonyloxy)propane-1,3-diyl dicyclohexanecarboxylate

Guidance literature:: With (S)-(-)-1-tris(trimethylsilyl)silyloxy-3-(3'-methyl-3'H-imidazol-4'-yl)-2-(2'',4'',6''-triisopropylbenzenesulfonylamino)propane; N-ethyl-N,N-diisopropylamine; In tetrachloromethane; chloroform; at 20 ℃; for 15h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/adsc.201100252

Reference yield:

: 1332880-56-4
2-phenyl-1,3-dioxan-5-yl 2,5-dihydro-1H-pyrrole-1-carboxylate

: 1332880-31-5
(R)-1-(cyclohexanecarbonyloxy)-3-hydroxypropan-2-yl 2,5-dihydro-1H-pyrrole-1-carboxylate

: 1332880-36-0
2-(2,5-dihydro-1H-pyrrole-1-carbonyloxy)propane-1,3-diyl dicyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: water; acetic acid / 3 h / 55 °C / Inert atmosphere

2: (S)-(-)-1-tris(trimethylsilyl)silyloxy-3-(3'-methyl-3'H-imidazol-4'-yl)-2-(2'',4'',6''-triisopropylbenzenesulfonylamino)propane; N-ethyl-N,N-diisopropylamine / tetrachloromethane; chloroform / 15 h / 20 °C / Inert atmosphere

With (S)-(-)-1-tris(trimethylsilyl)silyloxy-3-(3'-methyl-3'H-imidazol-4'-yl)-2-(2'',4'',6''-triisopropylbenzenesulfonylamino)propane; water; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrachloromethane; chloroform;
DOI:10.1002/adsc.201100252

Reference yield:

: 2,5-dihydro-1H-pyrrole-1-carbonyl chloride

: 1332880-31-5
(R)-1-(cyclohexanecarbonyloxy)-3-hydroxypropan-2-yl 2,5-dihydro-1H-pyrrole-1-carboxylate

: 1332880-36-0
2-(2,5-dihydro-1H-pyrrole-1-carbonyloxy)propane-1,3-diyl dicyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere

2: water; acetic acid / 3 h / 55 °C / Inert atmosphere

3: (S)-(-)-1-tris(trimethylsilyl)silyloxy-3-(3'-methyl-3'H-imidazol-4'-yl)-2-(2'',4'',6''-triisopropylbenzenesulfonylamino)propane; N-ethyl-N,N-diisopropylamine / tetrachloromethane; chloroform / 15 h / 20 °C / Inert atmosphere

With dmap; (S)-(-)-1-tris(trimethylsilyl)silyloxy-3-(3'-methyl-3'H-imidazol-4'-yl)-2-(2'',4'',6''-triisopropylbenzenesulfonylamino)propane; water; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; tetrachloromethane; chloroform; mineral oil;
DOI:10.1002/adsc.201100252