4-hydroxy-13-cis-retinal

Base Information

• Chemical Name: 4-hydroxy-13-cis-retinal
• CAS No.: 71423-68-2
• Molecular Formula: C₂₀H₂₈O₂
• Molecular Weight: 300.441
• Mol file: 71423-68-2.mol

Synonyms:4-hydroxy-13-cis-retinal

Chemical Property of 4-hydroxy-13-cis-retinal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-hydroxy-13-cis-retinal

There total 15 articles about 4-hydroxy-13-cis-retinal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.5%

C20H27NO → 4-Hydroxyretinal (18344-42-8,71423-68-2,117305-82-5,118353-35-8,140387-20-8,140387-21-9)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -5 - 0 ℃; for 1h; Inert atmosphere;

Reference yield:

13-cis-vitamin A aldehyde (472-86-6) → 13-cis-retinoic acid (4759-48-2) + 4-hydroxy-13-cis-retinal (71423-68-2)

Guidance literature:

With rabbit liver microsomal P₄₅₀ 1A₁ isozyme; NADPH; NADPH-cytochrome P₄₅₀ reductase; In phosphate buffer; at 30 ℃; for 0.25h; pH=7.4; Further Variations:; Reaction partners; Enzyme kinetics; Enzymatic reaction;

Reference yield:

vitamin A aldehyde (116-31-4,472-86-6,514-85-2,564-87-4,564-88-5,1436-55-1,23790-80-9,24315-14-8,34504-14-8,52918-36-2,56085-53-1,56085-54-2,56085-55-3,67529-90-2,67711-05-1,67737-35-3,67737-36-4,67737-37-5,67737-38-6,67737-39-7) → 4-hydroxy-13-cis-retinal (71423-68-2) + 4-hydroxy-all-trans-retinal (18344-42-8) + 5,6-epoxy-13-cis-retinal + 5,6-epoxy-5,6-dihydroretinal (739-13-9)

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; water; acetonitrile; at -15 ℃; for 0.0833333h; Title compound not separated from byproducts; red dim light;

DOI:10.1080/00397919908086018

upstream raw materials:

4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-buten-2-one

3-Methyl-1-(2,6,6-trimethyl-cyclohexen-⁽¹⁾-yl)-pentadien-(1,3)-saeure-⁽⁵⁾-nitril

3-methyl-5-(2,6,6-trimethylcyclohex-1-enyl)penta-2, 4-dienal

4-(1,3,3-trimethyl-7-oxabicyclo[4.1.0]hept-2-yl)-3-buten-2-one

Downstream raw materials:

4-keto-13-cis-retinal

4-keto-all-trans-retinal