Quinoline-8-sulfonic acid [5-(3-nitro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-amide

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Chemical Name:Quinoline-8-sulfonic acid [5-(3-nitro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-amide
CAS No.:215511-68-5
Molecular Formula:C₂₄H₁₇N₅O₅S
Molecular Weight:487.495
Hs Code.:

Synonyms:Quinoline-8-sulfonic acid [5-(3-nitro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-amide

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Chemical Property of Quinoline-8-sulfonic acid [5-(3-nitro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-amide

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Technology Process of Quinoline-8-sulfonic acid [5-(3-nitro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-amide

There total 5 articles about Quinoline-8-sulfonic acid [5-(3-nitro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 18704-37-5
quinoline-8-sulfonyl chloride

: 215511-64-1
3-Amino-5-(3-nitro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

: 215511-68-5
Quinoline-8-sulfonic acid [5-(3-nitro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-amide

Guidance literature:: With pyridine; 1) 0 deg C, 15 min, 2) reflux, 1.5 h;
DOI:10.1016/S0223-5234(98)80048-2

Reference yield:

: 3882-50-6
2-amino-3'-nitro-benzophenone

: 215511-68-5
Quinoline-8-sulfonic acid [5-(3-nitro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 1) N-methylmorpholine, iBuOCOCl / 1) CH₂Cl₂, 0 deg C, 15 min, 2) CH₂Cl₂, reflux, 20 min, r.t., overnight

2: NH₃, HgCl₂ / tetrahydrofuran / 3 h / 0 °C

3: 64 percent / NH₄OAc / acetic acid / Ambient temperature

4: 97 percent / 33percent HBr / acetic acid / 1) 0 deg C, 10 min, 2) 25 deg C, 30 min

5: 84 percent / pyridine / 1) 0 deg C, 15 min, 2) reflux, 1.5 h

With 4-methyl-morpholine; pyridine; ammonium acetate; ammonia; hydrogen bromide; mercury dichloride; isobutyl chloroformate; In tetrahydrofuran; acetic acid;
DOI:10.1016/S0223-5234(98)80048-2

Reference yield:

: 215511-62-9
[5-(3-Nitro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester

: 215511-68-5
Quinoline-8-sulfonic acid [5-(3-nitro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / 33percent HBr / acetic acid / 1) 0 deg C, 10 min, 2) 25 deg C, 30 min

2: 84 percent / pyridine / 1) 0 deg C, 15 min, 2) reflux, 1.5 h

With pyridine; hydrogen bromide; In acetic acid;
DOI:10.1016/S0223-5234(98)80048-2