(1S,2R,4R)-2-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{2,2,2-trifluoro-N-[5-(2,2,2-trifluoroacetamido)naphthalen-1-yl]acetamido}cyclopentyl 2-cyanoethyl diisopropylphosphoramidite

Base Information

Chemical Name:(1S,2R,4R)-2-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{2,2,2-trifluoro-N-[5-(2,2,2-trifluoroacetamido)naphthalen-1-yl]acetamido}cyclopentyl 2-cyanoethyl diisopropylphosphoramidite
CAS No.:1379651-03-2
Molecular Formula:C₅₀H₅₃F₆N₄O₇P
Molecular Weight:966.958
Hs Code.:

(1S,2R,4R)-2-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{2,2,2-trifluoro-N-[5-(2,2,2-trifluoroacetamido)naphthalen-1-yl]acetamido}cyclopentyl 2-cyanoethyl diisopropylphosphoramidite

Synonyms:(1S,2R,4R)-2-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{2,2,2-trifluoro-N-[5-(2,2,2-trifluoroacetamido)naphthalen-1-yl]acetamido}cyclopentyl 2-cyanoethyl diisopropylphosphoramidite

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Chemical Property of (1S,2R,4R)-2-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{2,2,2-trifluoro-N-[5-(2,2,2-trifluoroacetamido)naphthalen-1-yl]acetamido}cyclopentyl 2-cyanoethyl diisopropylphosphoramidite

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Technology Process of (1S,2R,4R)-2-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{2,2,2-trifluoro-N-[5-(2,2,2-trifluoroacetamido)naphthalen-1-yl]acetamido}cyclopentyl 2-cyanoethyl diisopropylphosphoramidite

There total 7 articles about (1S,2R,4R)-2-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{2,2,2-trifluoro-N-[5-(2,2,2-trifluoroacetamido)naphthalen-1-yl]acetamido}cyclopentyl 2-cyanoethyl diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1379650-83-5
N-[(1R,3R,4S)-3-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxycyclopentyl]-2,2,2-trifluoro-N-[5-(2,2,2-trifluoroacetylamino)naphthalen-1-yl]acetamide

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1379651-03-2
(1S,2R,4R)-2-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{2,2,2-trifluoro-N-[5-(2,2,2-trifluoroacetamido)naphthalen-1-yl]acetamido}cyclopentyl 2-cyanoethyl diisopropylphosphoramidite

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1055/s-0031-1289737

Reference yield:

: C₃₀H₃₀N₂O₂

: 1379651-03-2
(1S,2R,4R)-2-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{2,2,2-trifluoro-N-[5-(2,2,2-trifluoroacetamido)naphthalen-1-yl]acetamido}cyclopentyl 2-cyanoethyl diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 5 steps

1: sodium cyanoborohydride / tetrahydrofuran / 16 h

2: triethylamine / dichloromethane / 2 h / 0 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

4: pyridine / 4 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

With pyridine; palladium 10% on activated carbon; hydrogen; sodium cyanoborohydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1055/s-0031-1289737

Reference yield:

: (3S,4R)-N-{3-(benzyloxy)-4-[(benzyloxy)methyl]cyclopentyl}-2,2,2-trifluoro-N-[5-(2,2,2-trifluoroacetylamino)naphthalen-1-yl]acetamide

: 1379651-03-2
(1S,2R,4R)-2-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{2,2,2-trifluoro-N-[5-(2,2,2-trifluoroacetamido)naphthalen-1-yl]acetamido}cyclopentyl 2-cyanoethyl diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C

2: pyridine / 4 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

With pyridine; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol;
DOI:10.1055/s-0031-1289737