(E)-(2S,3R)-3-Methoxy-6-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-4-en-1-ol

Base Information

Chemical Name:(E)-(2S,3R)-3-Methoxy-6-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-4-en-1-ol
CAS No.:197227-72-8
Molecular Formula:C₁₇H₂₆O₄
Molecular Weight:294.391
Hs Code.:

Synonyms:(E)-(2S,3R)-3-Methoxy-6-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-4-en-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-(2S,3R)-3-Methoxy-6-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-4-en-1-ol

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Technology Process of (E)-(2S,3R)-3-Methoxy-6-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-4-en-1-ol

There total 11 articles about (E)-(2S,3R)-3-Methoxy-6-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-4-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1-Methoxy-4-((E)-(4R,5S)-4-methoxy-3,5-dimethyl-6-trityloxy-hex-2-enyloxymethyl)-benzene

: 197227-72-8
(E)-(2S,3R)-3-Methoxy-6-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-4-en-1-ol

Guidance literature:: With camphor-10-sulfonic acid; In methanol; dichloromethane; for 12h; Ambient temperature;
DOI:10.1016/S0040-4039(00)77485-5

Reference yield:

: tert-Butyl-[(E)-(2S,3R)-3-methoxy-6-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-4-enyloxy]-dimethyl-silane

: 197227-72-8
(E)-(2S,3R)-3-Methoxy-6-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-4-en-1-ol

Guidance literature:: With pyridinium p-toluenesulfonate; In ethanol; at 66 ℃; Yield given;
DOI:10.1016/S0040-4039(97)01605-5

Reference yield:

: ((S)-4-Benzyloxymethoxy-1,3-dimethyl-2-oxo-butyl)-phosphonic acid diethyl ester

: 197227-72-8
(E)-(2S,3R)-3-Methoxy-6-(4-methoxy-benzyloxy)-2,4-dimethyl-hex-4-en-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / H₂ / Pd / ethanol / 12 h / Ambient temperature

2: 72 percent / LiCl, DIPEA / acetonitrile / 24 h / Ambient temperature

3: 94 percent / Zn(BH₄)2 / diethyl ether / 0.5 h / 0 °C

4: 97 percent / pyridine / CH₂Cl₂ / 12 h / Ambient temperature

5: 100 percent / NaH / tetrahydrofuran / 12 h / Ambient temperature

6: 97 percent / CSA / methanol; CH₂Cl₂ / 12 h / Ambient temperature

With pyridine; zinc(II) tetrahydroborate; camphor-10-sulfonic acid; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; lithium chloride; palladium; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(00)77485-5