11-{4-[(2-phenothiazin-10-yl-acetylamino)methyl]benzyl}-1,4,8-tri(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

Base Information

• Chemical Name: 11-{4-[(2-phenothiazin-10-yl-acetylamino)methyl]benzyl}-1,4,8-tri(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane
• CAS No.: 929617-19-6
• Molecular Formula: C₄₇H₆₆N₆O₇S
• Molecular Weight: 859.143
• Mol file: 929617-19-6.mol

Synonyms:11-{4-[(2-phenothiazin-10-yl-acetylamino)methyl]benzyl}-1,4,8-tri(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

Chemical Property of 11-{4-[(2-phenothiazin-10-yl-acetylamino)methyl]benzyl}-1,4,8-tri(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11-{4-[(2-phenothiazin-10-yl-acetylamino)methyl]benzyl}-1,4,8-tri(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

There total 1 articles about 11-{4-[(2-phenothiazin-10-yl-acetylamino)methyl]benzyl}-1,4,8-tri(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

N-[(p-aminomethyl)benzyl]-1,4,8-tri(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclodecane (929617-18-5) + 2-(10H-phenothiazin-10-yl)acetic acid (25244-68-2) → 11-{4-[(2-phenothiazin-10-yl-acetylamino)methyl]benzyl}-1,4,8-tri(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane (929617-19-6)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 7.5h;

DOI:10.1016/j.bmcl.2006.10.094

Reference yield: 67.0%

11-{4-[(2-phenothiazin-10-yl-acetylamino)methyl]benzyl}-1,4,8-tri(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane (929617-19-6) → C32H42N6OS (929617-05-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2006.10.094

upstream raw materials:

N-[(p-aminomethyl)benzyl]-1,4,8-tri(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclodecane

2-(10H-phenothiazin-10-yl)acetic acid

Downstream raw materials:

C₃₂H₄₂N₆OS