(1R,2S)-2-(4-tolylsulfamoyl)-2-(methoxycarbonyl)-1-methylethyl β-aminocrotonate

Base Information

Chemical Name:(1R,2S)-2-(4-tolylsulfamoyl)-2-(methoxycarbonyl)-1-methylethyl β-aminocrotonate
CAS No.:166733-04-6
Molecular Formula:C₁₆H₂₂N₂O₆S
Molecular Weight:370.426
Hs Code.:

Synonyms:(1R,2S)-2-(4-tolylsulfamoyl)-2-(methoxycarbonyl)-1-methylethyl β-aminocrotonate

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Chemical Property of (1R,2S)-2-(4-tolylsulfamoyl)-2-(methoxycarbonyl)-1-methylethyl β-aminocrotonate

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Technology Process of (1R,2S)-2-(4-tolylsulfamoyl)-2-(methoxycarbonyl)-1-methylethyl β-aminocrotonate

There total 3 articles about (1R,2S)-2-(4-tolylsulfamoyl)-2-(methoxycarbonyl)-1-methylethyl β-aminocrotonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.5%

: 128107-92-6
(1R,2S)-2-(4-tolylsulfamoyl)-2-(methoxycarbonyl)-1-methylethyl acetoacetate

: 166733-04-6
(1R,2S)-2-(4-tolylsulfamoyl)-2-(methoxycarbonyl)-1-methylethyl β-aminocrotonate

Guidance literature:: With ammonia; toluene-4-sulfonic acid; In toluene; at 130 ℃; for 4h;
DOI:10.1021/jm00015a007

Reference yield:

: 43188-53-0
(2S,3R)-methyl-N-(4-methylphenylsulfonyl)-3-hydroxy-2-aminobutanoate

: 166733-04-6
(1R,2S)-2-(4-tolylsulfamoyl)-2-(methoxycarbonyl)-1-methylethyl β-aminocrotonate

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / 25 °C

2: 52.5 percent / NH₃(gas), p-TsOH / toluene / 4 h / 130 °C

With dmap; ammonia; toluene-4-sulfonic acid; In tetrahydrofuran; toluene;
DOI:10.1021/jm00015a007

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 166733-04-6
(1R,2S)-2-(4-tolylsulfamoyl)-2-(methoxycarbonyl)-1-methylethyl β-aminocrotonate

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / K₂CO₃ / ethyl acetate; H₂O / 20 h / 5 - 25 °C

2: 98 percent / 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / 25 °C

3: 52.5 percent / NH₃(gas), p-TsOH / toluene / 4 h / 130 °C

With dmap; ammonia; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; water; ethyl acetate; toluene;
DOI:10.1021/jm00015a007