penta-tert-butyl N-benzoyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-glutamate

Base Information

Chemical Name:penta-tert-butyl N-benzoyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-glutamate
CAS No.:117559-40-7
Molecular Formula:C₅₅H₈₁N₅O₁₆
Molecular Weight:1068.27
Hs Code.:

penta-tert-butyl N-<N-<N-<N-<4-<(benzyloxycarbonyl)amino>benzoyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-glutamate

Synonyms:penta-tert-butyl N-benzoyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-glutamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of penta-tert-butyl N-benzoyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-glutamate

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Technology Process of penta-tert-butyl N-benzoyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-glutamate

There total 8 articles about penta-tert-butyl N-benzoyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 37653-67-1
4-<(benzyloxycarbonyl)amino>benzoyl chloride

: 88443-03-2
L-γ-glutamyl-L-γ-glutamyl-L-γ-glutamyl-L-glutamic acid pentakis-t-butyl ester

: 117559-40-7
penta-tert-butyl N-benzoyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-glutamate

Guidance literature:: With 4-methyl-morpholine; In 1,4-dioxane; for 0.333333h; Ambient temperature;
DOI:10.1021/jm00121a029

Reference yield:

: 5891-45-2
(S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester

: 117559-40-7
penta-tert-butyl N-benzoyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-glutamate

Guidance literature:: Multi-step reaction with 7 steps

1: 1) N-methylmorpholine, isobutylchloroformate / 1) THF, -20 deg C, 10 min, 2) THF, -20 deg C, 10 min

2: H₂ / 10percent Pd/C / methanol

3: 1) N-methylmorpholine, isobutylchloroformate / 1) THF, -20 deg C, 10 min, 2) THF, -20 deg C, 10 min

4: H₂ / 10percent Pd/C / methanol

5: 1) N-methylmorpholine, isobutylchloroformate / 1) THF, -20 deg C, 10 min, 2) THF, -20 deg C, 10 min

6: H₂ / 10percent Pd/C / methanol

7: 88 percent / N-methylmorpholine / dioxane / 0.33 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In 1,4-dioxane; methanol;
DOI:10.1021/jm00121a029

Reference yield:

: 32677-01-3
L-glutamic acid di-tert-butyl ester hydrochloride

: 117559-40-7
penta-tert-butyl N-benzoyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-glutamate

Guidance literature:: Multi-step reaction with 7 steps

1: 1) N-methylmorpholine, isobutylchloroformate / 1) THF, -20 deg C, 10 min, 2) THF, -20 deg C, 10 min

2: H₂ / 10percent Pd/C / methanol

3: 1) N-methylmorpholine, isobutylchloroformate / 1) THF, -20 deg C, 10 min, 2) THF, -20 deg C, 10 min

4: H₂ / 10percent Pd/C / methanol

5: 1) N-methylmorpholine, isobutylchloroformate / 1) THF, -20 deg C, 10 min, 2) THF, -20 deg C, 10 min

6: H₂ / 10percent Pd/C / methanol

7: 88 percent / N-methylmorpholine / dioxane / 0.33 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In 1,4-dioxane; methanol;
DOI:10.1021/jm00121a029