4-((E)-((2R,3S)-3-(tert-butyldimethylsilyloxy)-2-(hydroxymethyl)pyrrolidin-1-ylimino)methyl)-2-chloro-3-methylbenzonitrile

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Chemical Name:4-((E)-((2R,3S)-3-(tert-butyldimethylsilyloxy)-2-(hydroxymethyl)pyrrolidin-1-ylimino)methyl)-2-chloro-3-methylbenzonitrile
CAS No.:1421375-83-8
Molecular Formula:C₂₀H₃₀ClN₃O₂Si
Molecular Weight:408.016
Hs Code.:

Synonyms:4-((E)-((2R,3S)-3-(tert-butyldimethylsilyloxy)-2-(hydroxymethyl)pyrrolidin-1-ylimino)methyl)-2-chloro-3-methylbenzonitrile

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Chemical Property of 4-((E)-((2R,3S)-3-(tert-butyldimethylsilyloxy)-2-(hydroxymethyl)pyrrolidin-1-ylimino)methyl)-2-chloro-3-methylbenzonitrile

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Technology Process of 4-((E)-((2R,3S)-3-(tert-butyldimethylsilyloxy)-2-(hydroxymethyl)pyrrolidin-1-ylimino)methyl)-2-chloro-3-methylbenzonitrile

There total 12 articles about 4-((E)-((2R,3S)-3-(tert-butyldimethylsilyloxy)-2-(hydroxymethyl)pyrrolidin-1-ylimino)methyl)-2-chloro-3-methylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1297544-91-2
2-chloro-4-formyl-3-methylbenzonitrile

: 1421375-79-2
((2R,3S)-1-amino-3-(tert-butyldimethylsilyloxy)pyrrolidin-2-yl)methanol

: 1421375-83-8
4-((E)-((2R,3S)-3-(tert-butyldimethylsilyloxy)-2-(hydroxymethyl)pyrrolidin-1-ylimino)methyl)-2-chloro-3-methylbenzonitrile

Guidance literature:: With acetic acid; at 20 ℃; for 3h;

Reference yield:

: 757247-75-9
2-chloro-4-iodo-3-methylbenzonitrile

: 1421375-83-8
4-((E)-((2R,3S)-3-(tert-butyldimethylsilyloxy)-2-(hydroxymethyl)pyrrolidin-1-ylimino)methyl)-2-chloro-3-methylbenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran; diethyl ether / 2 h / 0 °C / Inert atmosphere

1.2: 2 h / 0 °C

2.1: acetic acid / 3 h / 20 °C

With isopropylmagnesium chloride; acetic acid; In tetrahydrofuran; diethyl ether;

Reference yield:

: 496841-04-4,1378292-24-0
methyl (2S,3S)-3-hydroxypyrrolidine-2-carboxylate

: 1421375-83-8
4-((E)-((2R,3S)-3-(tert-butyldimethylsilyloxy)-2-(hydroxymethyl)pyrrolidin-1-ylimino)methyl)-2-chloro-3-methylbenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid; sodium nitrite / water / 4 h / 0 °C

2: 1H-imidazole / dichloromethane / 3 h / 20 °C

3: lithium triethylborohydride / tetrahydrofuran / 5 h / -78 - 20 °C

4: zinc; ammonium chloride / water; methanol / 1.5 h / 20 - 50 °C

5: acetic acid / 3 h / 20 °C

With 1H-imidazole; lithium triethylborohydride; ammonium chloride; acetic acid; zinc; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane; water;