ethyl 3-(1,2,3,6-tetrahydro-[1,1'-biphenyl]-4-yl)propanoate

Base Information

• Chemical Name: ethyl 3-(1,2,3,6-tetrahydro-[1,1'-biphenyl]-4-yl)propanoate
• CAS No.: 1411701-80-8
• Molecular Formula: C₁₇H₂₂O₂
• Molecular Weight: 258.36
• Mol file: 1411701-80-8.mol

Synonyms:ethyl 3-(1,2,3,6-tetrahydro-[1,1'-biphenyl]-4-yl)propanoate

Chemical Property of ethyl 3-(1,2,3,6-tetrahydro-[1,1'-biphenyl]-4-yl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-(1,2,3,6-tetrahydro-[1,1'-biphenyl]-4-yl)propanoate

There total 4 articles about ethyl 3-(1,2,3,6-tetrahydro-[1,1'-biphenyl]-4-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-(1-iodo-4-phenylcyclohexyl)propanoate (1411701-46-6) → ethyl 3-(1,2,3,6-tetrahydro-[1,1'-biphenyl]-4-yl)propanoate (1411701-80-8) + ethyl 3-(4-phenylcyclohexyl)prop-3-enoate (1411702-26-5)

Guidance literature:

With benzyl azide; In N,N-dimethyl-formamide; at 20 ℃; for 7h; Overall yield = 72 %; Overall yield = 110 mg;

DOI:10.1016/j.tet.2012.09.066

Reference yield:

4-phenyl-1-methylenecyclohexane (87143-17-7) + ethyl iodoacetae (623-48-3) → ethyl 3-(1,2,3,6-tetrahydro-[1,1'-biphenyl]-4-yl)propanoate (1411701-80-8) + ethyl 3-(4-phenylcyclohexyl)prop-3-enoate (1411702-26-5)

Guidance literature:

4-phenyl-1-methylenecyclohexane; ethyl iodoacetae; With triethyl borane; oxygen; In ethanol; water; at 20 ℃; for 1h; Darkness;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; water; at 20 ℃; Overall yield = 76 %; Overall yield = 196 mg; Darkness;

DOI:10.1055/s-0035-1560555

Reference yield:

1-phenyl-4-cyclohexanone (4894-75-1) → ethyl 3-(1,2,3,6-tetrahydro-[1,1'-biphenyl]-4-yl)propanoate (1411701-80-8) + ethyl 3-(4-phenylcyclohexyl)prop-3-enoate (1411702-26-5)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium tert-butylate / diethyl ether / 1.5 h / Reflux

2: triethyl borane / benzene / 6 h / 20 °C

3: benzyl azide / N,N-dimethyl-formamide / 7 h / 20 °C

With triethyl borane; potassium tert-butylate; benzyl azide; In diethyl ether; N,N-dimethyl-formamide; benzene;

DOI:10.1016/j.tet.2012.09.066

upstream raw materials:

ethyl 3-(1-iodo-4-phenylcyclohexyl)propanoate

1-phenyl-4-cyclohexanone

4-phenyl-1-methylenecyclohexane

ethyl iodoacetae