2-(tert-Butyl-dimethyl-silanyloxy)-1,2-dicyclohexyl-ethanone

Base Information

• Chemical Name: 2-(tert-Butyl-dimethyl-silanyloxy)-1,2-dicyclohexyl-ethanone
• CAS No.: 205884-18-0
• Molecular Formula: C₂₀H₃₈O₂Si
• Molecular Weight: 338.606
• Mol file: 205884-18-0.mol

Synonyms:2-(tert-Butyl-dimethyl-silanyloxy)-1,2-dicyclohexyl-ethanone

Chemical Property of 2-(tert-Butyl-dimethyl-silanyloxy)-1,2-dicyclohexyl-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-(tert-Butyl-dimethyl-silanyloxy)-1,2-dicyclohexyl-ethanone

There total 2 articles about 2-(tert-Butyl-dimethyl-silanyloxy)-1,2-dicyclohexyl-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1,2-dicyclohexyl-2-hydroxy-ethanone (55409-09-1) + t-butyldimethylsiyl triflate (69739-34-0) → 2-(tert-Butyl-dimethyl-silanyloxy)-1,2-dicyclohexyl-ethanone (205884-18-0)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 0.666667h;

DOI:10.1039/a709114a

Reference yield:

ethyl cyclohexanecarboxylate (3289-28-9) → 2-(tert-Butyl-dimethyl-silanyloxy)-1,2-dicyclohexyl-ethanone (205884-18-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / Na, (CH₃)3SiCl / diethyl ether / Heating

2: 88 percent / 2,6-lutidine / CH₂Cl₂ / 0.67 h / 0 °C

With 2,6-dimethylpyridine; chloro-trimethyl-silane; sodium; In diethyl ether; dichloromethane;

DOI:10.1039/a709114a

Reference yield: 70.0%

2-(tert-Butyl-dimethyl-silanyloxy)-1,2-dicyclohexyl-ethanone (205884-18-0) → cyclohexyl cyclohexylmethyl ketone (6713-49-1)

Guidance literature:

With dimethyl(phenyl)silyl lithium; In tetrahydrofuran; at -78 ℃; for 4h;

DOI:10.1039/a709114a

upstream raw materials:

1,2-dicyclohexyl-2-hydroxy-ethanone

t-butyldimethylsiyl triflate

ethyl cyclohexanecarboxylate

Downstream raw materials:

cyclohexyl cyclohexylmethyl ketone