Technology Process of 4-(Benzyloxy)-1-(6-methyl-1,2,3,4,5,6-hexahydroazepino[4, 3-b]indol-8-yl)pyridin-2(1H)-one
There total 9 articles about 4-(Benzyloxy)-1-(6-methyl-1,2,3,4,5,6-hexahydroazepino[4, 3-b]indol-8-yl)pyridin-2(1H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: hydrogenchloride / ethanol; water / 1 h / Reflux
2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / water; tetrahydrofuran / 0.75 h / 0 °C
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere
3.2: 2 h / 20 °C
4.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 20 h / Reflux
5.1: diphenyl phosphoryl azide / 4.5 h / 100 °C
5.2: Sonication
5.3: pH 7
6.1: borane-THF / tetrahydrofuran / 21 h / Reflux
6.2: 4.5 h / Reflux
7.1: caesium carbonate; 8-quinolinol / copper(l) iodide / dimethyl sulfoxide / 18 h / 133 °C / Inert atmosphere
8.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
With
hydrogenchloride; 8-quinolinol; borane-THF; diphenyl phosphoryl azide; hydroxylamine hydrochloride; sodium acetate; sodium hydride; caesium carbonate; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
copper(l) iodide;
In
tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: hydrogenchloride / ethanol; water / 1 h / Reflux
2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / water; tetrahydrofuran / 0.75 h / 0 °C
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere
3.2: 2 h / 20 °C
4.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 20 h / Reflux
5.1: diphenyl phosphoryl azide / 4.5 h / 100 °C
5.2: Sonication
5.3: pH 7
6.1: borane-THF / tetrahydrofuran / 21 h / Reflux
6.2: 4.5 h / Reflux
7.1: caesium carbonate; 8-quinolinol / copper(l) iodide / dimethyl sulfoxide / 18 h / 133 °C / Inert atmosphere
8.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
With
hydrogenchloride; 8-quinolinol; borane-THF; diphenyl phosphoryl azide; hydroxylamine hydrochloride; sodium acetate; sodium hydride; caesium carbonate; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
copper(l) iodide;
In
tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
![tert-butyl 8-((4-benzyloxy)-2-oxopyridin-1(2H)-yl)-6-methyl-3,4,5,6-tetrahydroazepino[4,3-b]indole-2(1H)-carboxylate](/Databaselist/images/loading.webp)
