N-(3,5-bis-(trifluoromethyl)phenyl)-2-methyl-2-phenylaziridine

Base Information

• Chemical Name: N-(3,5-bis-(trifluoromethyl)phenyl)-2-methyl-2-phenylaziridine
• CAS No.: 1007090-62-1
• Molecular Formula: C₁₇H₁₃F₆N
• Molecular Weight: 345.287
• Mol file: 1007090-62-1.mol

Synonyms:N-(3,5-bis-(trifluoromethyl)phenyl)-2-methyl-2-phenylaziridine

Chemical Property of N-(3,5-bis-(trifluoromethyl)phenyl)-2-methyl-2-phenylaziridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-(3,5-bis-(trifluoromethyl)phenyl)-2-methyl-2-phenylaziridine

There total 3 articles about N-(3,5-bis-(trifluoromethyl)phenyl)-2-methyl-2-phenylaziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3,5-bis(trifluoromethyl)phenyl azide + isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6) → N-(3,5-bis-(trifluoromethyl)phenyl)-2-methyl-2-phenylaziridine (1007090-62-1)

Guidance literature:

With 5,10,15,20-tetraphenylporphyrinato ruthenium carbonyl; In benzene; for 1h; Schlenk technique; Reflux; Inert atmosphere;

DOI:10.1002/adsc.202000175

Reference yield:

3,5-Bis(trifluoromethyl)phenyldiazomethane + isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6) → N-(3,5-bis-(trifluoromethyl)phenyl)-2-methyl-2-phenylaziridine (1007090-62-1)

Guidance literature:

With 5,10,15,20-tetraphenylporphyrinato ruthenium carbonyl; In benzene; at 90 ℃; for 1h; Time; Solvent; Temperature; Reflux;

DOI:10.1039/c6cy00207b

Reference yield:

3,5-Bis-(trifluoromethyl)aniline (328-74-5) → N-(3,5-bis-(trifluoromethyl)phenyl)-2-methyl-2-phenylaziridine (1007090-62-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C / Inert atmosphere; Schlenk technique

1.2: 3.75 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

2.1: C₁₀₀H₈₂F₄N₄O₁₂Ru / benzene / 2 h / Inert atmosphere; Reflux; Schlenk technique

With hydrogenchloride; C₁₀₀H₈₂F₄N₄O₁₂Ru; sodium nitrite; In water; benzene;

DOI:10.1002/ejic.201900829

upstream raw materials:

isopropenylbenzene

3,5-Bis-(trifluoromethyl)aniline