3-{1-(1,3-benzodioxol-5-yl)-2-[(4-isopropylphenyl)sulfonamido]-2-oxoethyl}-1-methyl-1H-6-indolecarboxamide

Base Information

Chemical Name:3-{1-(1,3-benzodioxol-5-yl)-2-[(4-isopropylphenyl)sulfonamido]-2-oxoethyl}-1-methyl-1H-6-indolecarboxamide
CAS No.:426815-20-5
Molecular Formula:C₂₈H₂₇N₃O₆S
Molecular Weight:533.605
Hs Code.:

Synonyms:3-{1-(1,3-benzodioxol-5-yl)-2-[(4-isopropylphenyl)sulfonamido]-2-oxoethyl}-1-methyl-1H-6-indolecarboxamide

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Chemical Property of 3-{1-(1,3-benzodioxol-5-yl)-2-[(4-isopropylphenyl)sulfonamido]-2-oxoethyl}-1-methyl-1H-6-indolecarboxamide

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Technology Process of 3-{1-(1,3-benzodioxol-5-yl)-2-[(4-isopropylphenyl)sulfonamido]-2-oxoethyl}-1-methyl-1H-6-indolecarboxamide

There total 9 articles about 3-{1-(1,3-benzodioxol-5-yl)-2-[(4-isopropylphenyl)sulfonamido]-2-oxoethyl}-1-methyl-1H-6-indolecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52415-29-9
6-bromo-1H-indole

: 426815-20-5
3-{1-(1,3-benzodioxol-5-yl)-2-[(4-isopropylphenyl)sulfonamido]-2-oxoethyl}-1-methyl-1H-6-indolecarboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: NaH / dimethylformamide / 25 °C

2.1: sBuLi / diethyl ether / -78 °C

2.2: diethyl ether / -78 - -20 °C

3.1: 2,6-dimethylpyridine / dimethylformamide / 8 h / 80 °C

4.1: NaOH / methanol; dioxane / 1 h / Heating

5.1: CH₂Cl₂ / 12 h / Heating

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 12 h / Heating

7.1: NaOH / tetrahydrofuran; methanol / 6 h / Heating

8.1: tetrahydrofuran / 12 h / Heating

9.1: NH₃

With 2,6-dimethylpyridine; sodium hydroxide; ammonia; sec.-butyllithium; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00660-6

Reference yield:

: 1204-32-6
methyl 1-methylindole-6-carboxylate

: 426815-20-5
3-{1-(1,3-benzodioxol-5-yl)-2-[(4-isopropylphenyl)sulfonamido]-2-oxoethyl}-1-methyl-1H-6-indolecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: 2,6-dimethylpyridine / dimethylformamide / 8 h / 80 °C

2: NaOH / methanol; dioxane / 1 h / Heating

3: CH₂Cl₂ / 12 h / Heating

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 12 h / Heating

5: NaOH / tetrahydrofuran; methanol / 6 h / Heating

6: tetrahydrofuran / 12 h / Heating

7: NH₃

With 2,6-dimethylpyridine; sodium hydroxide; ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00660-6

Reference yield:

: 125872-95-9
6-bromo-1-methyl-1H-indole

: 426815-20-5
3-{1-(1,3-benzodioxol-5-yl)-2-[(4-isopropylphenyl)sulfonamido]-2-oxoethyl}-1-methyl-1H-6-indolecarboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sBuLi / diethyl ether / -78 °C

1.2: diethyl ether / -78 - -20 °C

2.1: 2,6-dimethylpyridine / dimethylformamide / 8 h / 80 °C

3.1: NaOH / methanol; dioxane / 1 h / Heating

4.1: CH₂Cl₂ / 12 h / Heating

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 12 h / Heating

6.1: NaOH / tetrahydrofuran; methanol / 6 h / Heating

7.1: tetrahydrofuran / 12 h / Heating

8.1: NH₃

With 2,6-dimethylpyridine; sodium hydroxide; ammonia; sec.-butyllithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00660-6