Technology Process of C21H19F3N2O4
There total 5 articles about C21H19F3N2O4 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C11H14O4; 4-amino-2-trifluoromethylbenzonitrile;
With
dmap; thionyl chloride;
In
tetrahydrofuran;
at 20 ℃;
for 120h;
acetic anhydride;
With
pyridine;
In
tetrahydrofuran;
Further stages.;
DOI:10.1016/j.tetlet.2006.12.011
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 92 percent / KHCO3; aq. H2O2 / ethanol; acetonitrile / 72 h / 20 °C
2.1: Bacillus subtilis epoxide hydrolase / glycerol / 168 h / 20 °C
2.2: 43 percent / H2SO4 / H2O; glycerol / 0 - 20 °C
3.1: 97 percent / TEMPO; aq. NaClO; aq. NaClO2 / acetonitrile; aq. phosphate buffer / 48 h / 35 °C
4.1: SOCl2; DMAP / tetrahydrofuran / 120 h / 20 °C
4.2: 83 percent / pyridine / tetrahydrofuran
With
dmap; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite; thionyl chloride; dihydrogen peroxide; potassium hydrogencarbonate;
In
tetrahydrofuran; phosphate buffer; ethanol; glycerol; acetonitrile;
DOI:10.1016/j.tetlet.2006.12.011
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 97 percent / TEMPO; aq. NaClO; aq. NaClO2 / acetonitrile; aq. phosphate buffer / 48 h / 35 °C
2.1: SOCl2; DMAP / tetrahydrofuran / 120 h / 20 °C
2.2: 83 percent / pyridine / tetrahydrofuran
With
dmap; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite; thionyl chloride;
In
tetrahydrofuran; phosphate buffer; acetonitrile;
DOI:10.1016/j.tetlet.2006.12.011
