(S)-2-(2-Amino-benzoylamino)-pentanedioic acid di-tert-butyl ester

Base Information

• Chemical Name: (S)-2-(2-Amino-benzoylamino)-pentanedioic acid di-tert-butyl ester
• CAS No.: 204582-37-6
• Molecular Formula: C₂₀H₃₀N₂O₅
• Molecular Weight: 378.469
• Mol file: 204582-37-6.mol

Synonyms:(S)-2-(2-Amino-benzoylamino)-pentanedioic acid di-tert-butyl ester

Chemical Property of (S)-2-(2-Amino-benzoylamino)-pentanedioic acid di-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(2-Amino-benzoylamino)-pentanedioic acid di-tert-butyl ester

There total 1 articles about (S)-2-(2-Amino-benzoylamino)-pentanedioic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

L-glutamic acid di-tert-butyl ester hydrochloride (32677-01-3) + anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → (S)-2-(2-Amino-benzoylamino)-pentanedioic acid di-tert-butyl ester (204582-37-6)

Guidance literature:

With triethylamine; diethyl dicarbonate; In N,N-dimethyl-formamide; for 1h; Ambient temperature;

DOI:10.1248/cpb.46.255

Reference yield: 52.0%

(S)-2-(2-Amino-benzoylamino)-pentanedioic acid di-tert-butyl ester (204582-37-6) + 6,7-bis(palmitoyloxy)-4-thiaheptanoic acid (167767-89-7) → (S)-2-{2-[3-(2,3-Bis-hexadecanoyloxy-propylsulfanyl)-propionylamino]-benzoylamino}-pentanedioic acid di-tert-butyl ester (204582-78-5)

Guidance literature:

With pyridine; phosphorus trichloride; for 1h; Ambient temperature;

DOI:10.1248/cpb.46.255

Reference yield:

(S)-2-(2-Amino-benzoylamino)-pentanedioic acid di-tert-butyl ester (204582-37-6) → (S)-2-{2-[3-(2,3-Bis-hexadecanoyloxy-propylsulfanyl)-propionylamino]-benzoylamino}-pentanedioic acid

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / pyridine, PCl₃ / 1 h / Ambient temperature

2: 100 percent / TFA / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; trifluoroacetic acid; phosphorus trichloride; In dichloromethane;

DOI:10.1248/cpb.46.255

upstream raw materials:

L-glutamic acid di-tert-butyl ester hydrochloride

anthranilic acid

Downstream raw materials:

(S)-2-{2-[3-(2,3-Bis-hexadecanoyloxy-propylsulfanyl)-propionylamino]-benzoylamino}-pentanedioic acid di-tert-butyl ester