2-(methoxy)methoxyphenylmagnesium bromide

Base Information

• Chemical Name: 2-(methoxy)methoxyphenylmagnesium bromide
• CAS No.: 146746-34-1
• Molecular Formula: C₈H₉BrMgO₂
• Molecular Weight: 241.367
• Mol file: 146746-34-1.mol

Synonyms:2-(methoxy)methoxyphenylmagnesium bromide

Chemical Property of 2-(methoxy)methoxyphenylmagnesium bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-(methoxy)methoxyphenylmagnesium bromide

There total 1 articles about 2-(methoxy)methoxyphenylmagnesium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O-methoxymethylphenol (824-91-9) → 2-(methoxy)methoxyphenylmagnesium bromide (146746-34-1)

Guidance literature:

With n-butyllithium; magnesium bromide; Multistep reaction; 1) ether, hexane, RT, 3 h;

DOI:10.1021/jo00058a023

Reference yield: 94.0%

4-bromo-7-methylbenzo[c][1,2,5]thiadiazole (2255-80-3) + 2-(methoxy)methoxyphenylmagnesium bromide (146746-34-1) → 4-(2-(methoxymethoxy)phenyl)-7-methyl-2,1,3-benzothiadiazole (1338383-98-4)

Guidance literature:

2-(methoxy)methoxyphenylmagnesium bromide; With zinc(II) chloride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

4-bromo-7-methylbenzo[c][1,2,5]thiadiazole; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; for 2h; Inert atmosphere; Reflux;

DOI:10.1002/anie.201103792

Reference yield: 92.0%

2,2,2-Trifluoroacetaldehyde (75-90-1) + 2-(methoxy)methoxyphenylmagnesium bromide (146746-34-1) → 2,2,2-Trifluoro-1-(2-methoxymethoxy-phenyl)-ethanol (220025-58-1)

Guidance literature:

In tetrahydrofuran; at 0 ℃;

DOI:10.1039/a807157h

upstream raw materials:

O-methoxymethylphenol

Downstream raw materials:

9-<2-(methoxymethoxy)phenyl>anthracene

9-<2-(methoxymethoxy)phenyl>phenanthrene

methyl (S)-2-(tert-butoxycarbonylamino)-5-<2-(2-methoxymethoxy)phenyl>-5-oxopentanoate

(S)-2-tert-Butoxycarbonylamino-5-(2-methoxymethoxy-phenyl)-5-oxo-pentanoic acid ethyl ester