anhydro-2-phenyl-6,8-diethyl-5-hydroxy-7-oxo-1,3,4-thiadiazolo<3,2-a>pyrimidinium hydroxide

Base Information

• Chemical Name: anhydro-2-phenyl-6,8-diethyl-5-hydroxy-7-oxo-1,3,4-thiadiazolo<3,2-a>pyrimidinium hydroxide
• CAS No.: 91265-81-5
• Molecular Formula: C₁₅H₁₅N₃O₂S
• Molecular Weight: 301.369
• Mol file: 91265-81-5.mol

Synonyms:anhydro-2-phenyl-6,8-diethyl-5-hydroxy-7-oxo-1,3,4-thiadiazolo<3,2-a>pyrimidinium hydroxide

Chemical Property of anhydro-2-phenyl-6,8-diethyl-5-hydroxy-7-oxo-1,3,4-thiadiazolo<3,2-a>pyrimidinium hydroxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of anhydro-2-phenyl-6,8-diethyl-5-hydroxy-7-oxo-1,3,4-thiadiazolo<3,2-a>pyrimidinium hydroxide

There total 3 articles about anhydro-2-phenyl-6,8-diethyl-5-hydroxy-7-oxo-1,3,4-thiadiazolo<3,2-a>pyrimidinium hydroxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(ethylamino)-5-phenyl-1,3,4-thiadiazole (91265-79-1) + bis(2,4,6-trichlorophenyl) ethylmalonate (15781-72-3) → anhydro-2-phenyl-6,8-diethyl-5-hydroxy-7-oxo-1,3,4-thiadiazolo<3,2-a>pyrimidinium hydroxide (91265-81-5)

Guidance literature:

at 160 ℃; for 0.0833333h;

DOI:10.1021/jm00376a027

Reference yield:

N-(5-phenyl-1,3,4-thiadiazol-2-yl)acetamide (28898-88-6) → anhydro-2-phenyl-6,8-diethyl-5-hydroxy-7-oxo-1,3,4-thiadiazolo<3,2-a>pyrimidinium hydroxide (91265-81-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

2: 98 percent / 0.08 h / 160 °C

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/jm00376a027

Reference yield:

orthobenzoic acid trimethyl ester (707-07-3) → anhydro-2-phenyl-6,8-diethyl-5-hydroxy-7-oxo-1,3,4-thiadiazolo<3,2-a>pyrimidinium hydroxide (91265-81-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 30 percent / conc. aq. HCl / aq. ethanol / 1.) RT, 1.5 h, 2.) reflux, 1.5 h

2: 98 percent / 0.08 h / 160 °C

With hydrogenchloride; In ethanol;

DOI:10.1021/jm00376a027

upstream raw materials:

2-(ethylamino)-5-phenyl-1,3,4-thiadiazole

bis(2,4,6-trichlorophenyl) ethylmalonate

N-(5-phenyl-1,3,4-thiadiazol-2-yl)acetamide

orthobenzoic acid trimethyl ester