5-[1-(3,4-difluoro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-isoxazol-3-ylamine

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Chemical Name:5-[1-(3,4-difluoro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-isoxazol-3-ylamine
CAS No.:885225-94-5
Molecular Formula:C₁₉H₁₄F₃N₃O
Molecular Weight:357.335
Hs Code.:

Synonyms:5-[1-(3,4-difluoro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-isoxazol-3-ylamine

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Chemical Property of 5-[1-(3,4-difluoro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-isoxazol-3-ylamine

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Technology Process of 5-[1-(3,4-difluoro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-isoxazol-3-ylamine

There total 3 articles about 5-[1-(3,4-difluoro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-isoxazol-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 885225-93-4
3-[1-(3,4-difluoro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-3-oxo-propionitrile

: 885225-94-5
5-[1-(3,4-difluoro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-isoxazol-3-ylamine

Guidance literature:: 3-[1-(3,4-difluoro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-3-oxo-propionitrile; With hydroxyammonium sulfate; sodium hydroxide; In ethanol; water; for 17h; Reflux;

With hydrogenchloride; In ethanol; water; for 2h; regioselective reaction; Reflux;
DOI:10.1016/j.tetlet.2009.11.073

Reference yield: 29.0%

: 885225-95-6
3-[1-(2,4-dichloro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-3-oxo-propionitrile

: 885225-94-5
5-[1-(3,4-difluoro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-isoxazol-3-ylamine

: 1208065-26-2
C₁₉H₁₄F₃N₃O

Guidance literature:: With hydroxylamine hydrochloride; sodium hydroxide; In ethanol; water; at 80 ℃; for 17h;
DOI:10.1016/j.tetlet.2009.11.073

Reference yield:

: C₁₉H₁₄F₃N₃O₂

: 885225-94-5
5-[1-(3,4-difluoro-benzyl)-5-fluoro-3-methyl-1H-indol-7-yl]-isoxazol-3-ylamine

Guidance literature:: C₁₉H₁₄F₃N₃O₂; With hydrogenchloride; In water; at 100 ℃; for 3h;

With sodium hydrogencarbonate; In water; at 20 ℃; pH=8;