N-{5-chloro-2-[((2S)-3-{[1-(4-chlorobenzyl)piperidin-4-yl]amino}-2-hydroxy-2-methyl-propyl)oxy]-4-methoxyphenyl}propaneamide

Base Information

Chemical Name:N-{5-chloro-2-[((2S)-3-{[1-(4-chlorobenzyl)piperidin-4-yl]amino}-2-hydroxy-2-methyl-propyl)oxy]-4-methoxyphenyl}propaneamide
CAS No.:1151759-28-2
Molecular Formula:C₂₆H₃₅Cl₂N₃O₄
Molecular Weight:524.488
Hs Code.:

Synonyms:N-{5-chloro-2-[((2S)-3-{[1-(4-chlorobenzyl)piperidin-4-yl]amino}-2-hydroxy-2-methyl-propyl)oxy]-4-methoxyphenyl}propaneamide

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Chemical Property of N-{5-chloro-2-[((2S)-3-{[1-(4-chlorobenzyl)piperidin-4-yl]amino}-2-hydroxy-2-methyl-propyl)oxy]-4-methoxyphenyl}propaneamide

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Technology Process of N-{5-chloro-2-[((2S)-3-{[1-(4-chlorobenzyl)piperidin-4-yl]amino}-2-hydroxy-2-methyl-propyl)oxy]-4-methoxyphenyl}propaneamide

There total 1 articles about N-{5-chloro-2-[((2S)-3-{[1-(4-chlorobenzyl)piperidin-4-yl]amino}-2-hydroxy-2-methyl-propyl)oxy]-4-methoxyphenyl}propaneamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 924663-84-3
N-(5-chloro-4-methoxy-2-{[(2S)-methyloxiran-2-yl]methoxy}phenyl)propanamide

: 78471-44-0
1-(4-chloro-benzyl)-piperidin-4-ylamine

: 1151759-28-2
N-{5-chloro-2-[((2S)-3-{[1-(4-chlorobenzyl)piperidin-4-yl]amino}-2-hydroxy-2-methyl-propyl)oxy]-4-methoxyphenyl}propaneamide

Guidance literature:: With lithium perchlorate; In acetonitrile; for 18h; Heating / reflux;

Reference yield: 39.0%

: 1151759-28-2
N-{5-chloro-2-[((2S)-3-{[1-(4-chlorobenzyl)piperidin-4-yl]amino}-2-hydroxy-2-methyl-propyl)oxy]-4-methoxyphenyl}propaneamide

: 76-05-1
trifluoroacetic acid

: N-{5-chloro-2-[((2S)-3-{[1-(4-chlorobenzyl)piperidin-4-yl]amino}-2-hydroxy-2-methylpropyl)oxy]-4-hydroxyphenyl}propaneamide di-trifluoroacetate

Guidance literature:: N-{5-chloro-2-[((2S)-3-{[1-(4-chlorobenzyl)piperidin-4-yl]amino}-2-hydroxy-2-methyl-propyl)oxy]-4-methoxyphenyl}propaneamide; With boron tribromide; In dichloromethane; at 0 ℃; for 18h;

With methanol; In dichloromethane;

trifluoroacetic acid; In water; acetonitrile;