(4-Chloro-phenyl)-bis-methylsulfanyl-thioacetic acid S-methyl ester

Base Information

• Chemical Name: (4-Chloro-phenyl)-bis-methylsulfanyl-thioacetic acid S-methyl ester
• CAS No.: 195305-61-4
• Molecular Formula: C₁₁H₁₃ClOS₃
• Molecular Weight: 292.875
• Mol file: 195305-61-4.mol

Synonyms:(4-Chloro-phenyl)-bis-methylsulfanyl-thioacetic acid S-methyl ester

Chemical Property of (4-Chloro-phenyl)-bis-methylsulfanyl-thioacetic acid S-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-Chloro-phenyl)-bis-methylsulfanyl-thioacetic acid S-methyl ester

There total 1 articles about (4-Chloro-phenyl)-bis-methylsulfanyl-thioacetic acid S-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-(4-Chloro-phenyl)-2,2,2-tris-methylsulfanyl-ethanone (152423-67-1) → (4-Chloro-phenyl)-bis-methylsulfanyl-thioacetic acid S-methyl ester (195305-61-4)

Guidance literature:

With methanesulfonic acid; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1021/jo970683+

Reference yield: 91.0%

dimethyl sulfate (77-78-1) + (4-Chloro-phenyl)-bis-methylsulfanyl-thioacetic acid S-methyl ester (195305-61-4) → 2-(4-chloro-phenyl)-2-methylsulfanyl-thiopropionic acid S-methyl ester (197314-00-4)

Guidance literature:

(4-Chloro-phenyl)-bis-methylsulfanyl-thioacetic acid S-methyl ester; With potassium tert-butylate; In tetrahydrofuran; at 20 - 25 ℃; for 0.166667h;

dimethyl sulfate; In tetrahydrofuran; at 20 - 25 ℃; for 0.5h;

DOI:10.1055/s-2002-28521

Reference yield:

(4-Chloro-phenyl)-bis-methylsulfanyl-thioacetic acid S-methyl ester (195305-61-4) → 2-(4-Chloro-phenyl)-propionic acid (938-95-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: t-BuOK / tetrahydrofuran / 0.17 h / 20 - 25 °C

1.2: 91 percent / tetrahydrofuran / 0.5 h / 20 - 25 °C

2.1: 92 percent / MeSNa / acetonitrile / 1 h / 20 - 25 °C

3.1: 97 percent / aq. KOH / acetone / 2 h / Heating

With potassium hydroxide; potassium tert-butylate; mesna; In tetrahydrofuran; acetone; acetonitrile;

DOI:10.1055/s-2002-28521

upstream raw materials:

1-(4-Chloro-phenyl)-2,2,2-tris-methylsulfanyl-ethanone

Downstream raw materials:

2-(4-chloro-phenyl)-2-methylsulfanyl-thiopropionic acid S-methyl ester

2-(4-Chloro-phenyl)-propionic acid

2-(4-chloro-phenyl)-thiopropionic acid S-methyl ester